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Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

Author

Listed:
  • Scott A. Tomlins

    (Michigan Center for Translational Pathology)

  • Bharathi Laxman

    (Michigan Center for Translational Pathology)

  • Saravana M. Dhanasekaran

    (Michigan Center for Translational Pathology)

  • Beth E. Helgeson

    (Michigan Center for Translational Pathology)

  • Xuhong Cao

    (Michigan Center for Translational Pathology)

  • David S. Morris

    (Department of Urology,)

  • Anjana Menon

    (Michigan Center for Translational Pathology)

  • Xiaojun Jing

    (Michigan Center for Translational Pathology)

  • Qi Cao

    (Michigan Center for Translational Pathology)

  • Bo Han

    (Michigan Center for Translational Pathology)

  • Jindan Yu

    (Michigan Center for Translational Pathology)

  • Lei Wang

    (Michigan Center for Translational Pathology)

  • James E. Montie

    (Department of Urology,
    Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Mark A. Rubin

    (Brigham and Women’s Hospital
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Kenneth J. Pienta

    (Department of Urology,
    and
    Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Diane Roulston

    (Michigan Center for Translational Pathology)

  • Rajal B. Shah

    (Michigan Center for Translational Pathology
    Department of Urology,
    Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Sooryanarayana Varambally

    (Michigan Center for Translational Pathology
    Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Rohit Mehra

    (Michigan Center for Translational Pathology
    Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Arul M. Chinnaiyan

    (Michigan Center for Translational Pathology
    Department of Urology,
    Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

Abstract

Distinct translocation mechanisms and additional translocation partners for ETS genes are found in prostate cancer. This study also provides the first functional evidence that ETS gene deregulation can promote cancer cell invasion in cell lines and pre-malignant prostate lesions in a transgenic mouse model.

Suggested Citation

  • Scott A. Tomlins & Bharathi Laxman & Saravana M. Dhanasekaran & Beth E. Helgeson & Xuhong Cao & David S. Morris & Anjana Menon & Xiaojun Jing & Qi Cao & Bo Han & Jindan Yu & Lei Wang & James E. Montie, 2007. "Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer," Nature, Nature, vol. 448(7153), pages 595-599, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7153:d:10.1038_nature06024
    DOI: 10.1038/nature06024
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    Cited by:

    1. Adriano Zanin Zambom & Gregory J. Matthews, 2021. "Sure independence screening in the presence of missing data," Statistical Papers, Springer, vol. 62(2), pages 817-845, April.
    2. Petra Massoner & Karl G Kugler & Karin Unterberger & Ruprecht Kuner & Laurin A J Mueller & Maria Fälth & Georg Schäfer & Christof Seifarth & Simone Ecker & Irmgard Verdorfer & Armin Graber & Holger Sü, 2013. "Characterization of Transcriptional Changes in ERG Rearrangement-Positive Prostate Cancer Identifies the Regulation of Metabolic Sensors Such as Neuropeptide Y," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-11, February.
    3. Laia Simó-Riudalbas & Sandra Offner & Evarist Planet & Julien Duc & Laurence Abrami & Sagane Dind & Alexandre Coudray & Mairene Coto-Llerena & Caner Ercan & Salvatore Piscuoglio & Claus Lindbjerg Ande, 2022. "Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Alexander Martinez-Fundichely & Austin Dixon & Ekta Khurana, 2022. "Modeling tissue-specific breakpoint proximity of structural variations from whole-genomes to identify cancer drivers," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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