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Nuclear organization of the genome and the potential for gene regulation

Author

Listed:
  • Peter Fraser

    (Laboratory of Chromatin and Gene Expression, The Babraham Institute)

  • Wendy Bickmore

    (MRC Human Genetics Unit)

Abstract

Much work has been published on the cis-regulatory elements that affect gene function locally, as well as on the biochemistry of the transcription factors and chromatin- and histone-modifying complexes that influence gene expression. However, surprisingly little information is available about how these components are organized within the three-dimensional space of the nucleus. Technological advances are now helping to identify the spatial relationships and interactions of genes and regulatory elements in the nucleus and are revealing an unexpectedly extensive network of communication within and between chromosomes. A crucial unresolved issue is the extent to which this organization affects gene function, rather than just reflecting it.

Suggested Citation

  • Peter Fraser & Wendy Bickmore, 2007. "Nuclear organization of the genome and the potential for gene regulation," Nature, Nature, vol. 447(7143), pages 413-417, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7143:d:10.1038_nature05916
    DOI: 10.1038/nature05916
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    Cited by:

    1. Ramya Raviram & Pedro P Rocha & Christian L Müller & Emily R Miraldi & Sana Badri & Yi Fu & Emily Swanzey & Charlotte Proudhon & Valentina Snetkova & Richard Bonneau & Jane A Skok, 2016. "4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments," PLOS Computational Biology, Public Library of Science, vol. 12(3), pages 1-23, March.
    2. Markus J. Buehler & Theodor Ackbarow, 2008. "Nanomechanical strength mechanisms of hierarchical biological materials and tissues," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 11(6), pages 595-607.
    3. Antonio Scialdone & Mario Nicodemi, 2008. "Mechanics and Dynamics of X-Chromosome Pairing at X Inactivation," PLOS Computational Biology, Public Library of Science, vol. 4(12), pages 1-7, December.
    4. Vesa Aho & Sami Salminen & Salla Mattola & Alka Gupta & Felix Flomm & Beate Sodeik & Jens B Bosse & Maija Vihinen-Ranta, 2021. "Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane," PLOS Pathogens, Public Library of Science, vol. 17(12), pages 1-20, December.
    5. Jing Kang & Bing Xu & Ye Yao & Wei Lin & Conor Hennessy & Peter Fraser & Jianfeng Feng, 2011. "A Dynamical Model Reveals Gene Co-Localizations in Nucleus," PLOS Computational Biology, Public Library of Science, vol. 7(7), pages 1-16, July.

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