IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v433y2005i7027d10.1038_nature03315.html
   My bibliography  Save this article

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Author

Listed:
  • Lee P. Lim

    (Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.))

  • Nelson C. Lau

    (Massachusetts Institute of Technology)

  • Philip Garrett-Engele

    (Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.))

  • Andrew Grimson

    (Massachusetts Institute of Technology)

  • Janell M. Schelter

    (Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.))

  • John Castle

    (Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.))

  • David P. Bartel

    (Massachusetts Institute of Technology)

  • Peter S. Linsley

    (Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.))

  • Jason M. Johnson

    (Rosetta Inpharmatics (wholly owned subsidiary of Merck and Co.))

Abstract

microRNAs edit the message New work on microRNAs (miRNAs) sheds light on the nature of tissue-specific gene expression in humans. miRNAs act in plants and animals to regulate gene expression. Microarray analysis of messenger RNAs expressed in human cells containing miR-124, an miRNA expressed in the brain, or miR-1, found in muscle, shows that the miRNAs skew a cell's expression profile to resemble that of the miRNA's ‘home’ cells, regardless of source. This involves the downregulation of many target mRNA transcripts, as well as reduction of the amount of protein produced.

Suggested Citation

  • Lee P. Lim & Nelson C. Lau & Philip Garrett-Engele & Andrew Grimson & Janell M. Schelter & John Castle & David P. Bartel & Peter S. Linsley & Jason M. Johnson, 2005. "Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs," Nature, Nature, vol. 433(7027), pages 769-773, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7027:d:10.1038_nature03315
    DOI: 10.1038/nature03315
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature03315
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature03315?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Urmo Võsa & Tõnu Esko & Silva Kasela & Tarmo Annilo, 2015. "Altered Gene Expression Associated with microRNA Binding Site Polymorphisms," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-24, October.
    2. Panagiotis Alexiou & Manolis Maragkakis & Giorgio L Papadopoulos & Victor A Simmosis & Lin Zhang & Artemis G Hatzigeorgiou, 2010. "The DIANA-mirExTra Web Server: From Gene Expression Data to MicroRNA Function," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-7, February.
    3. Ho Thi Bich Phuong & Vien Ngoc Thach & Luong Hoang Ngan & Le Thi Truc Linh, 2018. "Using Bioinformatics to predict potential targets of Microrna-144 in osteoarthritis," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 43-52.
    4. Evelyn Zacharewicz & Paul Della Gatta & John Reynolds & Andrew Garnham & Tamsyn Crowley & Aaron P Russell & Séverine Lamon, 2014. "Identification of MicroRNAs Linked to Regulators of Muscle Protein Synthesis and Regeneration in Young and Old Skeletal Muscle," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-25, December.
    5. Rachel A Hillmer, 2015. "Systems Biology for Biologists," PLOS Pathogens, Public Library of Science, vol. 11(5), pages 1-6, May.
    6. Joel W Graff & Linda S Powers & Anne M Dickson & Jongkwang Kim & Anna C Reisetter & Ihab H Hassan & Karol Kremens & Thomas J Gross & Mary E Wilson & Martha M Monick, 2012. "Cigarette Smoking Decreases Global MicroRNA Expression in Human Alveolar Macrophages," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-13, August.
    7. Ran Elkon & Reuven Agami, 2008. "Removal of AU Bias from Microarray mRNA Expression Data Enhances Computational Identification of Active MicroRNAs," PLOS Computational Biology, Public Library of Science, vol. 4(10), pages 1-10, October.
    8. Weina Xu & Jinyi Liu & Huan Qi & Ruolin Si & Zhiguang Zhao & Zhiju Tao & Yuchuan Bai & Shipeng Hu & Xiaohan Sun & Yulin Cong & Haoye Zhang & Duchangjiang Fan & Long Xiao & Yangyang Wang & Yongbin Li &, 2024. "A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    9. Wenjie Zhu & Binghe Xu, 2014. "MicroRNA-21 Identified as Predictor of Cancer Outcome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-7, August.
    10. Hotaka Kobayashi & Robert H. Singer, 2022. "Single-molecule imaging of microRNA-mediated gene silencing in cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:433:y:2005:i:7027:d:10.1038_nature03315. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.