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Genomics, gene expression and DNA arrays

Author

Listed:
  • David J. Lockhart

    (Genomics Institute of the Novartis Research Foundation)

  • Elizabeth A. Winzeler

    (Genomics Institute of the Novartis Research Foundation)

Abstract

Experimental genomics in combination with the growing body of sequence information promise to revolutionize the way cells and cellular processes are studied. Information on genomic sequence can be used experimentally with high-density DNA arrays that allow complex mixtures of RNA and DNA to be interrogated in a parallel and quantitative fashion. DNA arrays can be used for many different purposes, most prominently to measure levels of gene expression (messenger RNA abundance) for tens of thousands of genes simultaneously. Measurements of gene expression and other applications of arrays embody much of what is implied by the term ‘genomics’; they are broad in scope, large in scale, and take advantage of all available sequence information for experimental design and data interpretation in pursuit of biological understanding.

Suggested Citation

  • David J. Lockhart & Elizabeth A. Winzeler, 2000. "Genomics, gene expression and DNA arrays," Nature, Nature, vol. 405(6788), pages 827-836, June.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6788:d:10.1038_35015701
    DOI: 10.1038/35015701
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    Cited by:

    1. Jens Keilwagen & Jan Grau & Ivan A Paponov & Stefan Posch & Marc Strickert & Ivo Grosse, 2011. "De-Novo Discovery of Differentially Abundant Transcription Factor Binding Sites Including Their Positional Preference," PLOS Computational Biology, Public Library of Science, vol. 7(2), pages 1-13, February.
    2. Andreas Wagner, 2001. "Estimating Coarse Gene Network Structure from Large-Scale Gene Perturbation Data," Working Papers 01-09-051, Santa Fe Institute.
    3. Kai Deng & Xin Zhang, 2022. "Tensor envelope mixture model for simultaneous clustering and multiway dimension reduction," Biometrics, The International Biometric Society, vol. 78(3), pages 1067-1079, September.

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