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Demethylation of the zygotic paternal genome

Author

Listed:
  • Wolfgang Mayer

    (Max Planck Institute of Molecular Genetics)

  • Alain Niveleau

    (Molecular and Structural Virology Unit, Université J. Fourier de Grenoble)

  • Jörn Walter

    (Max Planck Institute of Molecular Genetics)

  • Reinald Fundele

    (Max Planck Institute of Molecular Genetics)

  • Thomas Haaf

    (Max Planck Institute of Molecular Genetics)

Abstract

In mammals, both parental genomes undergo dramatic epigenetic changes after fertilization to form the diploid somatic genome. Here we show that the paternal genome in the mouse is significantly and actively demethylated within 6–8 hours of fertilization, before the onset of DNA replication, whereas the maternal genome is demethylated after several cleavage divisions. This active demethylation of the paternal genome may be associated with epigenetic remodelling of sperm chroma-tin, in order to establish parent-specific developmental programmes during early embryogenesis.

Suggested Citation

  • Wolfgang Mayer & Alain Niveleau & Jörn Walter & Reinald Fundele & Thomas Haaf, 2000. "Demethylation of the zygotic paternal genome," Nature, Nature, vol. 403(6769), pages 501-502, February.
    • Handle: RePEc:nat:nature:v:403:y:2000:i:6769:d:10.1038_35000656
    DOI: 10.1038/35000656
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    Cited by:

    1. van den Berg, Gerard J. & Pinger, Pia, 2014. "A Validation Study of Transgenerational Effects of Childhood Conditions on the Third Generation Offspring's Economic and Health Outcomes Potentially Driven by Epigenetic Imprinting," IZA Discussion Papers 7999, Institute of Labor Economics (IZA).
    2. I. Barnetova & I. Vackova & P. Firla, 2012. "Dynamics of epigenetic remodeling in interspecies porcine zygotes," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 57(2), pages 83-94.
    3. I. Barnetová & K. Okada, 2010. "Genome reprogramming during the first cell cycle in in vitro produced porcine embryos," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 55(2), pages 49-57.
    4. van den Berg, Gerard J. & Pinger, Pia R., 2016. "Transgenerational effects of childhood conditions on third generation health and education outcomes," Economics & Human Biology, Elsevier, vol. 23(C), pages 103-120.
    5. Allegra Angeloni & Skye Fissette & Deniz Kaya & Jillian M. Hammond & Hasindu Gamaarachchi & Ira W. Deveson & Robert J. Klose & Weiming Li & Xiaotian Zhang & Ozren Bogdanovic, 2024. "Extensive DNA methylome rearrangement during early lamprey embryogenesis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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