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A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II

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  • F. E. Matthews

    (MRC Biostatistics Unit, Institute of Public Health
    Institute of Health and Society, Faculty of Medicine, Newcastle University)

  • B. C. M. Stephan

    (Institute of Health and Society, Faculty of Medicine, Newcastle University)

  • L. Robinson

    (Institute of Health and Society, Faculty of Medicine, Newcastle University)

  • C. Jagger

    (Institute of Health and Society, Faculty of Medicine, Newcastle University)

  • L. E. Barnes

    (Cambridge Institute of Public Health, Cambridge University)

  • A. Arthur

    (School of Health Sciences, University of East Anglia)

  • C. Brayne

    (Cambridge Institute of Public Health, Cambridge University)

Abstract

Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ years in England and Wales (1989–1994). Three areas (CFAS I) were selected for new sampling two decades later (2008–2011) with same geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Here we report a 20% drop in incidence (95% CI: 0–40%), driven by a reduction in men across all ages above 65. In the UK we estimate 209,600 new dementia cases per year. This study was uniquely designed to test for differences across geography and time. A reduction of age-specific incidence means that the numbers of people estimated to develop dementia in any year has remained relatively stable.

Suggested Citation

  • F. E. Matthews & B. C. M. Stephan & L. Robinson & C. Jagger & L. E. Barnes & A. Arthur & C. Brayne, 2016. "A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II," Nature Communications, Nature, vol. 7(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11398
    DOI: 10.1038/ncomms11398
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    Cited by:

    1. Kazumasa Yamada, 2019. "An Acquaintance with An Aging Society," Social Sciences, MDPI, vol. 8(4), pages 1-27, April.
    2. Justine Schneider, 2018. "The Arts as a Medium for Care and Self-Care in Dementia: Arguments and Evidence," IJERPH, MDPI, vol. 15(6), pages 1-11, June.
    3. Daniel Palac & Tiffany Bullard & Jason D. Cohen & Lydia T. Nguyen & Raksha A. Mudar & Sean P. Mullen, 2019. "Effects of Traditional vs. iPad-Enhanced Aerobic Exercise on Wayfinding Efficacy and Cognition: A Pilot Randomized Controlled Trial," IJERPH, MDPI, vol. 16(18), pages 1-16, September.

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