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Host–parasite network structure is associated with community-level immunogenetic diversity

Author

Listed:
  • Shai Pilosof

    (Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev)

  • Miguel A. Fortuna

    (Integrative Ecology Group, Estación Biológica de Doñana (EBD-CSIC))

  • Jean-François Cosson

    (INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus International de Baillarguet)

  • Maxime Galan

    (INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus International de Baillarguet)

  • Chaisiri Kittipong

    (Faculty of Tropical Medicine, Mahidol University)

  • Alexis Ribas

    (Biodiversity Research Group, Faculty of Science, Udon Thani Rajabhat University)

  • Eran Segal

    (Weizmann Institute)

  • Boris R. Krasnov

    (Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev)

  • Serge Morand

    (Centre National de la Recherche Scientifique—Institut des Sciences de l’Évolution, Université Montpellier 2
    Centre de coopération International en Recherche Agronomique pour le Développement, Animal et Gestion Intégrée des Risques, Campus de Baillarguet
    Centre d'Infectiologie Christophe Mérieux du Laos)

  • Jordi Bascompte

    (Integrative Ecology Group, Estación Biológica de Doñana (EBD-CSIC))

Abstract

Genes of the major histocompatibility complex (MHC) encode proteins that recognize foreign antigens and are thus crucial for immune response. In a population of a single host species, parasite-mediated selection drives MHC allelic diversity. However, in a community-wide context, species interactions may modulate selection regimes because the prevalence of a given parasite in a given host may depend on its prevalence in other hosts. By combining network analysis with immunogenetics, we show that host species infected by similar parasites harbour similar alleles with similar frequencies. We further show, using a Bayesian approach, that the probability of mutual occurrence of a functional allele and a parasite in a given host individual is nonrandom and depends on other host–parasite interactions, driving co-evolution within subgroups of parasite species and functional alleles. Therefore, indirect effects among hosts and parasites can shape host MHC diversity, scaling it from the population to the community level.

Suggested Citation

  • Shai Pilosof & Miguel A. Fortuna & Jean-François Cosson & Maxime Galan & Chaisiri Kittipong & Alexis Ribas & Eran Segal & Boris R. Krasnov & Serge Morand & Jordi Bascompte, 2014. "Host–parasite network structure is associated with community-level immunogenetic diversity," Nature Communications, Nature, vol. 5(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6172
    DOI: 10.1038/ncomms6172
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    Cited by:

    1. Magdalena Meyer & Dominik W. Melville & Heather J. Baldwin & Kerstin Wilhelm & Evans Ewald Nkrumah & Ebenezer K. Badu & Samuel Kingsley Oppong & Nina Schwensow & Adam Stow & Peter Vallo & Victor M. Co, 2024. "Bat species assemblage predicts coronavirus prevalence," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Geut Galai & Xie He & Barak Rotblat & Shai Pilosof, 2023. "Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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