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Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain

Author

Listed:
  • Andrea I. Luppi

    (University of Cambridge
    McGill University)

  • Lynn Uhrig

    (Université Paris-Saclay, NeuroSpin Center
    Necker Hospital, AP-HP, Université de Paris Cité)

  • Jordy Tasserie

    (Université Paris-Saclay, NeuroSpin Center
    Harvard Medical School)

  • Camilo M. Signorelli

    (Université Paris-Saclay, NeuroSpin Center
    Université Libre de Bruxelles
    University of Oxford, Oxford)

  • Emmanuel A. Stamatakis

    (University of Cambridge)

  • Alain Destexhe

    (Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS))

  • Bechir Jarraya

    (Université Paris-Saclay, NeuroSpin Center
    Hopital Foch)

  • Rodrigo Cofre

    (Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS))

Abstract

A central challenge of neuroscience is to elucidate how brain function supports consciousness. Here, we combine the specificity of focal deep brain stimulation with fMRI coverage of the entire cortex, in awake and anaesthetised non-human primates. During propofol, sevoflurane, or ketamine anaesthesia, and subsequent restoration of responsiveness by electrical stimulation of the central thalamus, we investigate how loss of consciousness impacts distributed patterns of structure-function organisation across scales. We report that distributed brain activity under anaesthesia is increasingly constrained by brain structure across scales, coinciding with anaesthetic-induced collapse of multiple dimensions of hierarchical cortical organisation. These distributed signatures are observed across different anaesthetics, and they are reversed by electrical stimulation of the central thalamus, coinciding with recovery of behavioural markers of arousal. No such effects were observed upon stimulating the ventral lateral thalamus, demonstrating specificity. Overall, we identify consistent distributed signatures of consciousness that are orchestrated by specific thalamic nuclei.

Suggested Citation

  • Andrea I. Luppi & Lynn Uhrig & Jordy Tasserie & Camilo M. Signorelli & Emmanuel A. Stamatakis & Alain Destexhe & Bechir Jarraya & Rodrigo Cofre, 2024. "Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46382-w
    DOI: 10.1038/s41467-024-46382-w
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