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Comparative connectomics of dauer reveals developmental plasticity

Author

Listed:
  • Hyunsoo Yim

    (Seoul National University)

  • Daniel T. Choe

    (Seoul National University)

  • J. Alexander Bae

    (Seoul National University)

  • Myung-kyu Choi

    (Seoul National University)

  • Hae-Mook Kang

    (Seoul National University)

  • Ken C. Q. Nguyen

    (Albert Einstein College of Medicine)

  • Soungyub Ahn

    (Seoul National University)

  • Sang-kyu Bahn

    (Korea Brain Research Institute
    Korea Brain Research Institute)

  • Heeseung Yang

    (Seoul National University)

  • David H. Hall

    (Albert Einstein College of Medicine)

  • Jinseop S. Kim

    (Korea Brain Research Institute
    Sungkyunkwan University)

  • Junho Lee

    (Seoul National University
    Seoul National University)

Abstract

A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with distinct behavioral characteristics, by volumetric reconstruction and automated synapse detection using deep learning. With the basic architecture of the nervous system preserved, structural changes in neurons, large or small, were closely associated with connectivity changes, which in turn evoked dauer-specific behaviors such as nictation. Graph theoretical analyses revealed significant dauer-specific rewiring of sensory neuron connectivity and increased clustering within motor neurons in the dauer connectome. We suggest that the nervous system in the nematode has evolved to respond to harsh environments by developing a quantitatively and qualitatively differentiated connectome.

Suggested Citation

  • Hyunsoo Yim & Daniel T. Choe & J. Alexander Bae & Myung-kyu Choi & Hae-Mook Kang & Ken C. Q. Nguyen & Soungyub Ahn & Sang-kyu Bahn & Heeseung Yang & David H. Hall & Jinseop S. Kim & Junho Lee, 2024. "Comparative connectomics of dauer reveals developmental plasticity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45943-3
    DOI: 10.1038/s41467-024-45943-3
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