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Tuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application

Author

Listed:
  • Peng Jiang

    (Tsinghua University)

  • Ludan Zhang

    (Peking University School and Hospital of Stomatology)

  • Xiaolong Liu

    (Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences)

  • Chenliang Ye

    (Tsinghua University)

  • Peng Zhu

    (Tsinghua University)

  • Ting Tan

    (Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences)

  • Dingsheng Wang

    (Tsinghua University)

  • Yuguang Wang

    (Peking University School and Hospital of Stomatology)

Abstract

The reaction system of hydrogen peroxide (H2O2) catalyzed by nanozyme has a broad prospect in antibacterial treatment. However, the complex catalytic activities of nanozymes lead to multiple pathways reacting in parallel, causing uncertain antibacterial results. New approach to effectively regulate the multiple catalytic activities of nanozyme is in urgent need. Herein, Cu single site is modified on nanoceria with various catalytic activities, such as peroxidase-like activity (POD) and hydroxyl radical antioxidant capacity (HORAC). Benefiting from the interaction between coordinated Cu and CeO2 substrate, POD is enhanced while HORAC is inhibited, which is further confirmed by density functional theory (DFT) calculations. Cu-CeO2 + H2O2 system shows good antibacterial properties both in vitro and in vivo. In this work, the strategy based on the interaction between coordinated metal and carrier provides a general clue for optimizing the complex activities of nanozymes.

Suggested Citation

  • Peng Jiang & Ludan Zhang & Xiaolong Liu & Chenliang Ye & Peng Zhu & Ting Tan & Dingsheng Wang & Yuguang Wang, 2024. "Tuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45255-6
    DOI: 10.1038/s41467-024-45255-6
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    References listed on IDEAS

    as
    1. Hao-Xin Liu & Shan-Qing Li & Wei-Wei Wang & Wen-Zhu Yu & Wu-Jun Zhang & Chao Ma & Chun-Jiang Jia, 2022. "Partially sintered copper‒ceria as excellent catalyst for the high-temperature reverse water gas shift reaction," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Feng Gao & Tianyi Shao & Yunpeng Yu & Yujie Xiong & Lihua Yang, 2021. "Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Jinwei Xu & Xueli Zheng & Zhiping Feng & Zhiyi Lu & Zewen Zhang & William Huang & Yanbin Li & Djordje Vuckovic & Yuanqing Li & Sheng Dai & Guangxu Chen & Kecheng Wang & Hansen Wang & James K. Chen & W, 2021. "Organic wastewater treatment by a single-atom catalyst and electrolytically produced H2O2," Nature Sustainability, Nature, vol. 4(3), pages 233-241, March.
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