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Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis

Author

Listed:
  • Nathan Bénac

    (Univ. Bordeaux, CNRS, IINS, UMR 5297)

  • G. Ezequiel Saraceno

    (Univ. Bordeaux, CNRS, IINS, UMR 5297)

  • Corey Butler

    (Univ. Bordeaux, CNRS, IINS, UMR 5297)

  • Nahoko Kuga

    (The University of Tokyo
    Tohoku University)

  • Yuya Nishimura

    (The University of Tokyo)

  • Taiki Yokoi

    (Tohoku University)

  • Ping Su

    (University of Toronto)

  • Takuya Sasaki

    (The University of Tokyo
    Tohoku University)

  • Mar Petit-Pedrol

    (Univ. Bordeaux, CNRS, IINS, UMR 5297)

  • Rémi Galland

    (Univ. Bordeaux, CNRS, IINS, UMR 5297)

  • Vincent Studer

    (Univ. Bordeaux, CNRS, IINS, UMR 5297)

  • Fang Liu

    (University of Toronto)

  • Yuji Ikegaya

    (The University of Tokyo
    Center for Information and Neural Networks, Suita City
    The University of Tokyo)

  • Jean-Baptiste Sibarita

    (Univ. Bordeaux, CNRS, IINS, UMR 5297)

  • Laurent Groc

    (Univ. Bordeaux, CNRS, IINS, UMR 5297)

Abstract

Direct interactions between receptors at the neuronal surface have long been proposed to tune signaling cascades and neuronal communication in health and disease. Yet, the lack of direct investigation methods to measure, in live neurons, the interaction between different membrane receptors at the single molecule level has raised unanswered questions on the biophysical properties and biological roles of such receptor interactome. Using a multidimensional spectral single molecule-localization microscopy (MS-SMLM) approach, we monitored the interaction between two membrane receptors, i.e. glutamatergic NMDA (NMDAR) and G protein-coupled dopamine D1 (D1R) receptors. The transient interaction was randomly observed along the dendritic tree of hippocampal neurons. It was higher early in development, promoting the formation of NMDAR-D1R complexes in an mGluR5- and CK1-dependent manner, favoring NMDAR clusters and synaptogenesis in a dopamine receptor signaling-independent manner. Preventing the interaction in the neonate, and not adult, brain alters in vivo spontaneous neuronal network activity pattern in male mice. Thus, a weak and transient interaction between NMDAR and D1R plays a structural and functional role in the developing brain.

Suggested Citation

  • Nathan Bénac & G. Ezequiel Saraceno & Corey Butler & Nahoko Kuga & Yuya Nishimura & Taiki Yokoi & Ping Su & Takuya Sasaki & Mar Petit-Pedrol & Rémi Galland & Vincent Studer & Fang Liu & Yuji Ikegaya &, 2024. "Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44301-z
    DOI: 10.1038/s41467-023-44301-z
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    References listed on IDEAS

    as
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