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Respiration modulates sleep oscillations and memory reactivation in humans

Author

Listed:
  • Thomas Schreiner

    (Ludwig-Maximilians-Universität München)

  • Marit Petzka

    (Max Planck Institute for Human Development
    University of Hamburg)

  • Tobias Staudigl

    (Ludwig-Maximilians-Universität München)

  • Bernhard P. Staresina

    (University of Oxford
    University of Oxford)

Abstract

The beneficial effect of sleep on memory consolidation relies on the precise interplay of slow oscillations and spindles. However, whether these rhythms are orchestrated by an underlying pacemaker has remained elusive. Here, we tested the relationship between respiration, which has been shown to impact brain rhythms and cognition during wake, sleep-related oscillations and memory reactivation in humans. We re-analysed an existing dataset, where scalp electroencephalography and respiration were recorded throughout an experiment in which participants (N = 20) acquired associative memories before taking a nap. Our results reveal that respiration modulates the emergence of sleep oscillations. Specifically, slow oscillations, spindles as well as their interplay (i.e., slow-oscillation_spindle complexes) systematically increase towards inhalation peaks. Moreover, the strength of respiration - slow-oscillation_spindle coupling is linked to the extent of memory reactivation (i.e., classifier evidence in favour of the previously learned stimulus category) during slow-oscillation_spindles. Our results identify a clear association between respiration and memory consolidation in humans and highlight the role of brain-body interactions during sleep.

Suggested Citation

  • Thomas Schreiner & Marit Petzka & Tobias Staudigl & Bernhard P. Staresina, 2023. "Respiration modulates sleep oscillations and memory reactivation in humans," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43450-5
    DOI: 10.1038/s41467-023-43450-5
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    References listed on IDEAS

    as
    1. Nikolaos Karalis & Anton Sirota, 2022. "Breathing coordinates cortico-hippocampal dynamics in mice during offline states," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Thomas Schreiner & Elisabeth Kaufmann & Soheyl Noachtar & Jan-Hinnerk Mehrkens & Tobias Staudigl, 2022. "The human thalamus orchestrates neocortical oscillations during NREM sleep," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Randolph F. Helfrich & Janna D. Lendner & Bryce A. Mander & Heriberto Guillen & Michelle Paff & Lilit Mnatsakanyan & Sumeet Vadera & Matthew P. Walker & Jack J. Lin & Robert T. Knight, 2019. "Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    4. Ofer Perl & Aharon Ravia & Mica Rubinson & Ami Eisen & Timna Soroka & Nofar Mor & Lavi Secundo & Noam Sobel, 2019. "Human non-olfactory cognition phase-locked with inhalation," Nature Human Behaviour, Nature, vol. 3(5), pages 501-512, May.
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