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Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy

Author

Listed:
  • Chaojie Yu

    (Tianjin University
    Tianjin University)

  • Mingyue Shi

    (Tianjin University
    Tongji University)

  • Shaoshuai He

    (Tianjin University
    Thrust of Sustainable Energy and Environment, The Hong Kong University of Science and Technology (Guangzhou))

  • Mengmeng Yao

    (Tianjin University)

  • Hong Sun

    (North China University of Science and Technology)

  • Zhiwei Yue

    (North China University of Science and Technology)

  • Yuwei Qiu

    (Tianjin University)

  • Baijun Liu

    (Tianjin University)

  • Lei Liang

    (Tianjin University)

  • Zhongming Zhao

    (Tianjin University)

  • Fanglian Yao

    (Tianjin University
    Tianjin University)

  • Hong Zhang

    (Tianjin University
    Tianjin University)

  • Junjie Li

    (Tianjin University
    Tianjin University)

Abstract

With advances in tissue engineering and bioelectronics, flexible electronic hydrogels that allow conformal tissue integration, online precision diagnosis, and simultaneous tissue regeneration are expected to be the next-generation platform for the treatment of myocardial infarction. Here, we report a functionalized polyaniline-based chronological adhesive hydrogel patch (CAHP) that achieves spatiotemporally selective and conformal embedded integration with a moist and dynamic epicardium surface. Significantly, CAHP has high adhesion toughness, rapid self-healing ability, and enhanced electrochemical performance, facilitating sensitive sensing of cardiac mechanophysiology-mediated microdeformations and simultaneous improvement of myocardial fibrosis-induced electrophysiology. As a result, the flexible CAHP platform monitors diastolic-systolic amplitude and rhythm in the infarcted myocardium online while effectively inhibiting ventricular remodeling, promoting vascular regeneration, and improving electrophysiological function through electrocoupling therapy. Therefore, this diagnostic and therapeutic integration provides a promising monitorable treatment protocol for cardiac disease.

Suggested Citation

  • Chaojie Yu & Mingyue Shi & Shaoshuai He & Mengmeng Yao & Hong Sun & Zhiwei Yue & Yuwei Qiu & Baijun Liu & Lei Liang & Zhongming Zhao & Fanglian Yao & Hong Zhang & Junjie Li, 2023. "Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42008-9
    DOI: 10.1038/s41467-023-42008-9
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    References listed on IDEAS

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