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Neural mechanisms for the localization of unexpected external motion

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  • Suma Chinta

    (Purdue University
    Purdue University)

  • Scott R. Pluta

    (Purdue University
    Purdue University)

Abstract

To localize objects during active sensing, animals must differentiate stimuli caused by volitional movement from real-world object motion. To determine a neural basis for this ability, we examined the mouse superior colliculus (SC), which contains multiple egocentric maps of sensorimotor space. By placing mice in a whisker-guided virtual reality, we discovered a rapidly adapting tactile response that transiently emerged during externally generated gains in whisker contact. Responses to self-generated touch that matched self-generated history were significantly attenuated, revealing that transient response magnitude is controlled by sensorimotor predictions. The magnitude of the transient response gradually decreased with repetitions in external motion, revealing a slow habituation based on external history. The direction of external motion was accurately encoded in the firing rates of transiently responsive neurons. These data reveal that whisker-specific adaptation and sensorimotor predictions in SC neurons enhance the localization of unexpected, externally generated changes in tactile space.

Suggested Citation

  • Suma Chinta & Scott R. Pluta, 2023. "Neural mechanisms for the localization of unexpected external motion," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41755-z
    DOI: 10.1038/s41467-023-41755-z
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