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Homeostatic synaptic plasticity rescues neural coding reliability

Author

Listed:
  • Eyal Rozenfeld

    (Tel Aviv University
    Tel Aviv University)

  • Nadine Ehmann

    (Leipzig University)

  • Julia E. Manoim

    (Tel Aviv University)

  • Robert J. Kittel

    (Leipzig University)

  • Moshe Parnas

    (Tel Aviv University
    Tel Aviv University)

Abstract

To survive, animals must recognize reoccurring stimuli. This necessitates a reliable stimulus representation by the neural code. While synaptic transmission underlies the propagation of neural codes, it is unclear how synaptic plasticity can maintain coding reliability. By studying the olfactory system of Drosophila melanogaster, we aimed to obtain a deeper mechanistic understanding of how synaptic function shapes neural coding in the live, behaving animal. We show that the properties of the active zone (AZ), the presynaptic site of neurotransmitter release, are critical for generating a reliable neural code. Reducing neurotransmitter release probability of olfactory sensory neurons disrupts both neural coding and behavioral reliability. Strikingly, a target-specific homeostatic increase of AZ numbers rescues these defects within a day. These findings demonstrate an important role for synaptic plasticity in maintaining neural coding reliability and are of pathophysiological interest by uncovering an elegant mechanism through which the neural circuitry can counterbalance perturbations.

Suggested Citation

  • Eyal Rozenfeld & Nadine Ehmann & Julia E. Manoim & Robert J. Kittel & Moshe Parnas, 2023. "Homeostatic synaptic plasticity rescues neural coding reliability," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38575-6
    DOI: 10.1038/s41467-023-38575-6
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    References listed on IDEAS

    as
    1. Eyal Rozenfeld & Merav Tauber & Yair Ben-Chaim & Moshe Parnas, 2021. "GPCR voltage dependence controls neuronal plasticity and behavior," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Georg Dietzl & Doris Chen & Frank Schnorrer & Kuan-Chung Su & Yulia Barinova & Michaela Fellner & Beate Gasser & Kaolin Kinsey & Silvia Oppel & Susanne Scheiblauer & Africa Couto & Vincent Marra & Kry, 2007. "A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila," Nature, Nature, vol. 448(7150), pages 151-156, July.
    3. Shawn R. Olsen & Rachel I. Wilson, 2008. "Lateral presynaptic inhibition mediates gain control in an olfactory circuit," Nature, Nature, vol. 452(7190), pages 956-960, April.
    4. Atefeh Pooryasin & Marta Maglione & Marco Schubert & Tanja Matkovic-Rachid & Sayed-mohammad Hasheminasab & Ulrike Pech & André Fiala & Thorsten Mielke & Stephan J. Sigrist, 2021. "Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    5. Nadine Ehmann & Sebastian van de Linde & Amit Alon & Dmitrij Ljaschenko & Xi Zhen Keung & Thorge Holm & Annika Rings & Aaron DiAntonio & Stefan Hallermann & Uri Ashery & Manfred Heckmann & Markus Saue, 2014. "Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
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