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Antigen discrimination by T cells relies on size-constrained microvillar contact

Author

Listed:
  • Edward Jenkins

    (University of Oxford
    University of Oxford)

  • Markus Körbel

    (University of Cambridge)

  • Caitlin O’Brien-Ball

    (University of Oxford
    University of Oxford)

  • James McColl

    (University of Cambridge)

  • Kevin Y. Chen

    (University of Cambridge)

  • Mateusz Kotowski

    (University of Oxford
    University of Oxford)

  • Jane Humphrey

    (University of Cambridge)

  • Anna H. Lippert

    (University of Cambridge)

  • Heather Brouwer

    (University of Oxford
    University of Oxford)

  • Ana Mafalda Santos

    (University of Oxford
    University of Oxford)

  • Steven F. Lee

    (University of Cambridge)

  • Simon J. Davis

    (University of Oxford
    University of Oxford)

  • David Klenerman

    (University of Cambridge)

Abstract

T cells use finger-like protrusions called ‘microvilli’ to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a target cell’s glycocalyx. Here, T cells are observed to use microvilli to breach a model glycocalyx barrier, forming numerous small (

Suggested Citation

  • Edward Jenkins & Markus Körbel & Caitlin O’Brien-Ball & James McColl & Kevin Y. Chen & Mateusz Kotowski & Jane Humphrey & Anna H. Lippert & Heather Brouwer & Ana Mafalda Santos & Steven F. Lee & Simon, 2023. "Antigen discrimination by T cells relies on size-constrained microvillar contact," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36855-9
    DOI: 10.1038/s41467-023-36855-9
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    References listed on IDEAS

    as
    1. Eoin F. McKinney & James C. Lee & David R. W. Jayne & Paul A. Lyons & Kenneth G. C. Smith, 2015. "T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection," Nature, Nature, vol. 523(7562), pages 612-616, July.
    2. Charles R. Harris & K. Jarrod Millman & Stéfan J. Walt & Ralf Gommers & Pauli Virtanen & David Cournapeau & Eric Wieser & Julian Taylor & Sebastian Berg & Nathaniel J. Smith & Robert Kern & Matti Picu, 2020. "Array programming with NumPy," Nature, Nature, vol. 585(7825), pages 357-362, September.
    3. Shashank J. Patel & Neville E. Sanjana & Rigel J. Kishton & Arash Eidizadeh & Suman K. Vodnala & Maggie Cam & Jared J. Gartner & Li Jia & Seth M. Steinberg & Tori N. Yamamoto & Anand S. Merchant & Gau, 2017. "Identification of essential genes for cancer immunotherapy," Nature, Nature, vol. 548(7669), pages 537-542, August.
    4. Jason Yi & Lakshmi Balagopalan & Tiffany Nguyen & Katherine M. McIntire & Lawrence E. Samelson, 2019. "TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    5. Yunmin Jung & Lai Wen & Amnon Altman & Klaus Ley, 2021. "CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
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    Cited by:

    1. Joann Chongsaritsinsuk & Alexandra D. Steigmeyer & Keira E. Mahoney & Mia A. Rosenfeld & Taryn M. Lucas & Courtney M. Smith & Alice Li & Deniz Ince & Fiona L. Kearns & Alexandria S. Battison & Marie A, 2023. "Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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