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CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I

Author

Listed:
  • Cheng-Jie Zhou

    (Inner Mongolia University)

  • Xing-Yue Wang

    (Inner Mongolia University)

  • Yan-Hua Dong

    (Inner Mongolia University)

  • Dong-Hui Wang

    (Inner Mongolia University)

  • Zhe Han

    (Inner Mongolia University)

  • Xiao-Jie Zhang

    (Inner Mongolia University)

  • Qing-Yuan Sun

    (Guangdong Second Provincial General Hospital)

  • John Carroll

    (Monash University)

  • Cheng-Guang Liang

    (Inner Mongolia University)

Abstract

Chromosome segregation is initiated by cohesin degradation, which is driven by anaphase-promoting complex/cyclosome (APC/C). Chromosome cohesin is removed by activated separase, with the degradation of securin and cyclinB1. Dynamin-related protein 1 (DRP1), a component of the mitochondrial fission machinery, is related to cyclin dynamics in mitosis progression. Here, we show that DRP1 is recruited to the kinetochore by centromeric Centromere protein F (CENP-F) after nuclear envelope breakdown in mouse oocytes. Loss of DRP1 during prometaphase leads to premature cohesin degradation and chromosome segregation. Importantly, acute DRP1 depletion activates separase by initiating cyclinB1 and securin degradation during the metaphase-to-anaphase transition. Finally, we demonstrate that DRP1 is bound to APC2 to restrain the E3 ligase activity of APC/C. In conclusion, DRP1 is a CENP-F-dependent atypical spindle assembly checkpoint (SAC) protein that modulates metaphase-to-anaphase transition by controlling APC/C activity during meiosis I in oocytes.

Suggested Citation

  • Cheng-Jie Zhou & Xing-Yue Wang & Yan-Hua Dong & Dong-Hui Wang & Zhe Han & Xiao-Jie Zhang & Qing-Yuan Sun & John Carroll & Cheng-Guang Liang, 2022. "CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35461-5
    DOI: 10.1038/s41467-022-35461-5
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    References listed on IDEAS

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    2. S. K. Reddy & M. Rape & W. A. Margansky & M. W. Kirschner, 2007. "Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation," Nature, Nature, vol. 446(7138), pages 921-925, April.
    3. Ibtissem Nabti & Rosanna Grimes & Hema Sarna & Petros Marangos & John Carroll, 2017. "Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II," Nature Communications, Nature, vol. 8(1), pages 1-9, August.
    4. Michael T. Lin & M. Flint Beal, 2006. "Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases," Nature, Nature, vol. 443(7113), pages 787-795, October.
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