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Greater genetic diversity is needed in human pluripotent stem cell models

Author

Listed:
  • Sulagna Ghosh

    (Broad Institute of MIT and Harvard
    Harvard University)

  • Ralda Nehme

    (Broad Institute of MIT and Harvard
    Harvard University)

  • Lindy E. Barrett

    (Broad Institute of MIT and Harvard
    Harvard University)

Abstract

While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and studies. Here, we discuss the importance of incorporating diverse ancestries in these models to improve equity and accelerate biological discovery.

Suggested Citation

  • Sulagna Ghosh & Ralda Nehme & Lindy E. Barrett, 2022. "Greater genetic diversity is needed in human pluripotent stem cell models," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34940-z
    DOI: 10.1038/s41467-022-34940-z
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    1. Helena Kilpinen & Angela Goncalves & Andreas Leha & Vackar Afzal & Kaur Alasoo & Sofie Ashford & Sendu Bala & Dalila Bensaddek & Francesco Paolo Casale & Oliver J. Culley & Petr Danecek & Adam Faulcon, 2017. "Common genetic variation drives molecular heterogeneity in human iPSCs," Nature, Nature, vol. 546(7658), pages 370-375, June.
    2. Ananyo Choudhury & Shaun Aron & Laura R. Botigué & Dhriti Sengupta & Gerrit Botha & Taoufik Bensellak & Gordon Wells & Judit Kumuthini & Daniel Shriner & Yasmina J. Fakim & Anisah W. Ghoorah & Eileen , 2020. "High-depth African genomes inform human migration and health," Nature, Nature, vol. 586(7831), pages 741-748, October.
    3. Florian T. Merkle & Sulagna Ghosh & Nolan Kamitaki & Jana Mitchell & Yishai Avior & Curtis Mello & Seva Kashin & Shila Mekhoubad & Dusko Ilic & Maura Charlton & Genevieve Saphier & Robert E. Handsaker, 2017. "Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations," Nature, Nature, vol. 545(7653), pages 229-233, May.
    4. Konrad J. Karczewski & Laurent C. Francioli & Grace Tiao & Beryl B. Cummings & Jessica Alföldi & Qingbo Wang & Ryan L. Collins & Kristen M. Laricchia & Andrea Ganna & Daniel P. Birnbaum & Laura D. Gau, 2020. "The mutational constraint spectrum quantified from variation in 141,456 humans," Nature, Nature, vol. 581(7809), pages 434-443, May.
    5. Helena Kilpinen & Angela Goncalves & Andreas Leha & Vackar Afzal & Kaur Alasoo & Sofie Ashford & Sendu Bala & Dalila Bensaddek & Francesco Paolo Casale & Oliver J. Culley & Petr Danecek & Adam Faulcon, 2017. "Correction: Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs," Nature, Nature, vol. 546(7660), pages 686-686, June.
    6. Nolan Kamitaki & Aswin Sekar & Robert E. Handsaker & Heather Rivera & Katherine Tooley & David L. Morris & Kimberly E. Taylor & Christopher W. Whelan & Philip Tombleson & Loes M. Olde Loohuis & Michae, 2020. "Complement genes contribute sex-biased vulnerability in diverse disorders," Nature, Nature, vol. 582(7813), pages 577-581, June.
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    2. Matthew Tegtmeyer & Jatin Arora & Samira Asgari & Beth A. Cimini & Ajay Nadig & Emily Peirent & Dhara Liyanage & Gregory P. Way & Erin Weisbart & Aparna Nathan & Tiffany Amariuta & Kevin Eggan & Marzi, 2024. "High-dimensional phenotyping to define the genetic basis of cellular morphology," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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