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Hospitalisation and mortality risk of SARS-COV-2 variant omicron sub-lineage BA.2 compared to BA.1 in England

Author

Listed:
  • H. H. Webster

    (UKHSA COVID-19 National Epidemiology Cell)

  • T. Nyberg

    (University of Cambridge)

  • M. A. Sinnathamby

    (UKHSA COVID-19 National Epidemiology Cell)

  • N. Abdul Aziz

    (UKHSA COVID-19 National Epidemiology Cell)

  • N. Ferguson

    (Imperial College London)

  • G. Seghezzo

    (UKHSA COVID-19 National Epidemiology Cell)

  • P. B. Blomquist

    (UKHSA Outbreak Surveillance Team)

  • J. Bridgen

    (UKHSA Outbreak Surveillance Team)

  • M. Chand

    (UKHSA Genomics and Public Health Analysis)

  • N. Groves

    (UKHSA Genomics and Public Health Analysis)

  • R. Myers

    (UKHSA Genomics and Public Health Analysis)

  • R. Hope

    (UKHSA COVID-19 National Epidemiology Cell)

  • E. Ashano

    (UKHSA HCAI, Fungal, AMR, AMU & Sepsis Division)

  • J. Lopez-Bernal

    (UKHSA COVID-19 Surveillance Cell
    NIHR Health Protection Research Unit for Respiratory Infections)

  • D. Angelis

    (University of Cambridge
    UKHSA Statistics, Modelling and Economics Department
    UKHSA Joint Modelling Team
    NIHR Health Protection Research Unit for Behavioural Science and Evaluation)

  • G. Dabrera

    (UKHSA COVID-19 National Epidemiology Cell)

  • A. M. Presanis

    (University of Cambridge)

  • S. Thelwall

    (UKHSA COVID-19 National Epidemiology Cell)

Abstract

The Omicron variant of SARS-CoV-2 became the globally dominant variant in early 2022. A sub-lineage of the Omicron variant (BA.2) was identified in England in January 2022. Here, we investigated hospitalisation and mortality risks of COVID-19 cases with the Omicron sub-lineage BA.2 (n = 258,875) compared to BA.1 (n = 984,337) in a large cohort study in England. We estimated the risk of hospital attendance, hospital admission or death using multivariable stratified proportional hazards regression models. After adjustment for confounders, BA.2 cases had lower or similar risks of death (HR = 0.80, 95% CI 0.71–0.90), hospital admission (HR = 0.88, 95% CI 0.83–0.94) and any hospital attendance (HR = 0.98, 95% CI 0.95–1.01). These findings that the risk of severe outcomes following infection with BA.2 SARS-CoV-2 was slightly lower or equivalent to the BA.1 sub-lineage can inform public health strategies in countries where BA.2 is spreading.

Suggested Citation

  • H. H. Webster & T. Nyberg & M. A. Sinnathamby & N. Abdul Aziz & N. Ferguson & G. Seghezzo & P. B. Blomquist & J. Bridgen & M. Chand & N. Groves & R. Myers & R. Hope & E. Ashano & J. Lopez-Bernal & D. , 2022. "Hospitalisation and mortality risk of SARS-COV-2 variant omicron sub-lineage BA.2 compared to BA.1 in England," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33740-9
    DOI: 10.1038/s41467-022-33740-9
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    References listed on IDEAS

    as
    1. Erik Volz & Swapnil Mishra & Meera Chand & Jeffrey C. Barrett & Robert Johnson & Lily Geidelberg & Wes R. Hinsley & Daniel J. Laydon & Gavin Dabrera & Áine O’Toole & Robert Amato & Manon Ragonnet-Cron, 2021. "Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England," Nature, Nature, vol. 593(7858), pages 266-269, May.
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