IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31253-z.html
   My bibliography  Save this article

Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63

Author

Listed:
  • Songling Li

    (Fudan University
    Institute of Molecular Physiology, Shenzhen Bay Laboratory)

  • Bingxue Li

    (Fudan University
    Institute of Molecular Physiology, Shenzhen Bay Laboratory)

  • Li Gao

    (Fudan University)

  • Jingwen Wang

    (Fudan University)

  • Zhiqiang Yan

    (Fudan University
    Institute of Molecular Physiology, Shenzhen Bay Laboratory)

Abstract

Birds, reptiles and insects have the ability to discriminate humidity levels that influence their survival and geographic distribution. Insects are particularly susceptible to humidity changes due to high surface area to volume ratios, but it remains unclear how humidity sensors transduce humidity signals. Here we identified Or42b-expressing olfactory sensory neurons, which are required for moisture attraction in Drosophila. The sensilla housing Or42b neurons show cuticular deformations upon moist air stimuli, indicating a conversion of humidity into mechanical force. Accordingly, we found Or42b neurons directly respond to humidity changes and rely on the mechanosensitive ion channel TMEM63 to mediate humidity sensing (hygrosensation). Expressing human TMEM63B in Tmem63 mutant flies rescued their defective phenotype in moisture attraction, demonstrating functional conservation. Thus, our results reveal a role of Tmem63 in hygrosensation and support the strategy to detect humidity by transforming it into a mechanical stimulus, which is unique in sensory transduction.

Suggested Citation

  • Songling Li & Bingxue Li & Li Gao & Jingwen Wang & Zhiqiang Yan, 2022. "Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31253-z
    DOI: 10.1038/s41467-022-31253-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31253-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31253-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Julia L. Semmelhack & Jing W. Wang, 2009. "Select Drosophila glomeruli mediate innate olfactory attraction and aversion," Nature, Nature, vol. 459(7244), pages 218-223, May.
    2. Allison F. Carey & Guirong Wang & Chih-Ying Su & Laurence J. Zwiebel & John R. Carlson, 2010. "Odorant reception in the malaria mosquito Anopheles gambiae," Nature, Nature, vol. 464(7285), pages 66-71, March.
    3. Lei Liu & Yuhong Li & Runping Wang & Chong Yin & Qian Dong & Huey Hing & Changsoo Kim & Michael J. Welsh, 2007. "Drosophila hygrosensation requires the TRP channels water witch and nanchung," Nature, Nature, vol. 450(7167), pages 294-298, November.
    4. Yang Xiang & Quan Yuan & Nina Vogt & Loren L. Looger & Lily Yeh Jan & Yuh Nung Jan, 2010. "Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall," Nature, Nature, vol. 468(7326), pages 921-926, December.
    5. Fang Yuan & Huimin Yang & Yan Xue & Dongdong Kong & Rui Ye & Chijun Li & Jingyuan Zhang & Lynn Theprungsirikul & Tayler Shrift & Bryan Krichilsky & Douglas M. Johnson & Gary B. Swift & Yikun He & Jame, 2014. "OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis," Nature, Nature, vol. 514(7522), pages 367-371, October.
    6. Zhiqiang Yan & Wei Zhang & Ye He & David Gorczyca & Yang Xiang & Li E. Cheng & Shan Meltzer & Lily Yeh Jan & Yuh Nung Jan, 2013. "Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation," Nature, Nature, vol. 493(7431), pages 221-225, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yuqi Qin & Daqi Yu & Dan Wu & Jiangqing Dong & William Thomas Li & Chang Ye & Kai Chit Cheung & Yingyi Zhang & Yun Xu & YongQiang Wang & Yun Stone Shi & Shangyu Dang, 2023. "Cryo-EM structure of TMEM63C suggests it functions as a monomer," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Shannon Trombley & Jackson Powell & Pavithran Guttipatti & Andrew Matamoros & Xiaohui Lin & Tristan O’Harrow & Tobias Steinschaden & Leann Miles & Qin Wang & Shuchao Wang & Jingyun Qiu & Qingyang Li &, 2023. "Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Yuqi Qin & Daqi Yu & Dan Wu & Jiangqing Dong & William Thomas Li & Chang Ye & Kai Chit Cheung & Yingyi Zhang & Yun Xu & YongQiang Wang & Yun Stone Shi & Shangyu Dang, 2023. "Cryo-EM structure of TMEM63C suggests it functions as a monomer," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Edmund J. Norris & Joel R. Coats, 2017. "Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control," IJERPH, MDPI, vol. 14(2), pages 1-15, January.
    4. Fangmin Zhou & Alexandra-Madelaine Tichy & Bibi Nusreen Imambocus & Shreyas Sakharwade & Francisco J. Rodriguez Jimenez & Marco González Martínez & Ishrat Jahan & Margarita Habib & Nina Wilhelmy & Van, 2023. "Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. Pranjul Singh & Shefali Goyal & Smith Gupta & Sanket Garg & Abhinav Tiwari & Varad Rajput & Alexander Shakeel Bates & Arjit Kant Gupta & Nitin Gupta, 2023. "Combinatorial encoding of odors in the mosquito antennal lobe," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Xiao Xu & Long Zhang & Xingbo Zhao, 2023. "The Aversive Response of the Locust Locusta migratoria to 3-Octanone, an Odorant from Fungal Pathogens, Is Mediated by a Chemosensory Protein," Agriculture, MDPI, vol. 13(8), pages 1-13, August.
    7. Tyler R. Sizemore & Julius Jonaitis & Andrew M. Dacks, 2023. "Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    8. Martin F Strube-Bloss & Austin Brown & Johannes Spaethe & Thomas Schmitt & Wolfgang Rössler, 2015. "Extracting the Behaviorally Relevant Stimulus: Unique Neural Representation of Farnesol, a Component of the Recruitment Pheromone of Bombus terrestris," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-16, September.
    9. Mingfeng Zhang & Yuanyue Shan & Charles D. Cox & Duanqing Pei, 2023. "A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    10. Mami Nakamizo-Dojo & Kenichi Ishii & Jiro Yoshino & Masato Tsuji & Kazuo Emoto, 2023. "Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    11. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    12. Liangyu Tao & Samuel P. Wechsler & Vikas Bhandawat, 2023. "Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    13. Zhengyang Kong & Elvis K. Boahen & Dong Jun Kim & Fenglong Li & Joo Sung Kim & Hyukmin Kweon & So Young Kim & Hanbin Choi & Jin Zhu & Wu Ying & Do Hwan Kim, 2024. "Ultrafast underwater self-healing piezo-ionic elastomer via dynamic hydrophobic-hydrolytic domains," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    14. Kenjiro Yoshimura & Kazuko Iida & Hidetoshi Iida, 2021. "MCAs in Arabidopsis are Ca2+-permeable mechanosensitive channels inherently sensitive to membrane tension," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    15. Rishabh Chandak & Baranidharan Raman, 2023. "Neural manifolds for odor-driven innate and acquired appetitive preferences," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    16. Jingying Zhang & Grigory Maksaev & Peng Yuan, 2023. "Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31253-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.