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Auditory processing remains sensitive to environmental experience during adolescence in a rodent model

Author

Listed:
  • Kelsey L. Anbuhl

    (New York University)

  • Justin D. Yao

    (New York University)

  • Robert A. Hotz

    (New York University)

  • Todd M. Mowery

    (New York University
    Rutgers University)

  • Dan H. Sanes

    (New York University
    New York University
    New York University
    Neuroscience Institute at NYU Langone School of Medicine)

Abstract

Elevated neural plasticity during development contributes to dramatic improvements in perceptual, motor, and cognitive skills. However, malleable neural circuits are vulnerable to environmental influences that may disrupt behavioral maturation. While these risks are well-established prior to sexual maturity (i.e., critical periods), the degree of neural vulnerability during adolescence remains uncertain. Here, we induce transient hearing loss (HL) spanning adolescence in gerbils, and ask whether behavioral and neural maturation are disrupted. We find that adolescent HL causes a significant perceptual deficit that can be attributed to degraded auditory cortex processing, as assessed with wireless single neuron recordings and within-session population-level analyses. Finally, auditory cortex brain slices from adolescent HL animals reveal synaptic deficits that are distinct from those typically observed after critical period deprivation. Taken together, these results show that diminished adolescent sensory experience can cause long-lasting behavioral deficits that originate, in part, from a dysfunctional cortical circuit.

Suggested Citation

  • Kelsey L. Anbuhl & Justin D. Yao & Robert A. Hotz & Todd M. Mowery & Dan H. Sanes, 2022. "Auditory processing remains sensitive to environmental experience during adolescence in a rodent model," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30455-9
    DOI: 10.1038/s41467-022-30455-9
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    References listed on IDEAS

    as
    1. Daniel B. Polley & John H. Thompson & Wei Guo, 2013. "Brief hearing loss disrupts binaural integration during two early critical periods of auditory cortex development," Nature Communications, Nature, vol. 4(1), pages 1-13, December.
    2. Leslie L. Davidson & Elena L. Grigorenko & Michael J. Boivin & Elizabeth Rapa & Alan Stein, 2015. "A focus on adolescence to reduce neurological, mental health and substance-use disability," Nature, Nature, vol. 527(7578), pages 161-166, November.
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