IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30165-2.html
   My bibliography  Save this article

WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

Author

Listed:
  • Shiu-Ling Chen

    (National Chi Nan University)

  • Bo-Ting Liu

    (National Chi Nan University)

  • Wang-Pao Lee

    (College of Medicine, Chang Gung University)

  • Sin-Bo Liao

    (National Chi Nan University
    National Tsing Hua University)

  • Yao-Bang Deng

    (National Chi Nan University)

  • Chia-Lin Wu

    (College of Medicine, Chang Gung University
    Chang Gung Memorial Hospital
    National Tsing Hua University)

  • Shuk-Man Ho

    (National Chi Nan University)

  • Bing-Xian Shen

    (National Chi Nan University)

  • Guan-Hock Khoo

    (Tunghai University)

  • Wei-Chiang Shiu

    (National Chi Nan University)

  • Chih-Hsuan Chang

    (Tunghai University
    National Tsing Hua University
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes)

  • Hui-Wen Shih

    (Tunghai University)

  • Jung-Kun Wen

    (Institute of Biological Chemistry, Academia Sinica)

  • Tsuo-Hung Lan

    (School of Medicine, National Yang Ming Chiao Tung University
    Tsaotun Psychiatric Center, Ministry of Health and Welfare
    Taichung Veterans General Hospital
    Center for Neuropsychiatric Research, National Health Research Institutes)

  • Chih-Chien Lin

    (School of Medicine, National Yang Ming Chiao Tung University)

  • Yu-Chen Tsai

    (Tunghai University)

  • Huey-Fen Tzeng

    (National Chi Nan University)

  • Tsai-Feng Fu

    (National Chi Nan University)

Abstract

The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABAA receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.

Suggested Citation

  • Shiu-Ling Chen & Bo-Ting Liu & Wang-Pao Lee & Sin-Bo Liao & Yao-Bang Deng & Chia-Lin Wu & Shuk-Man Ho & Bing-Xian Shen & Guan-Hock Khoo & Wei-Chiang Shiu & Chih-Hsuan Chang & Hui-Wen Shih & Jung-Kun W, 2022. "WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30165-2
    DOI: 10.1038/s41467-022-30165-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30165-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30165-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Shu-Yun Kuo & Chia-Lin Wu & Min-Yen Hsieh & Chen-Ta Lin & Rong-Kun Wen & Lien-Cheng Chen & Yu-Hui Chen & Yhu-Wei Yu & Horng-Dar Wang & Yi-Ju Su & Chun-Ju Lin & Cian-Yi Yang & Hsien-Yu Guan & Pei-Yu Wa, 2015. "PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    2. Vanessa Ruta & Sandeep Robert Datta & Maria Luisa Vasconcelos & Jessica Freeland & Loren L. Looger & Richard Axel, 2010. "A dimorphic pheromone circuit in Drosophila from sensory input to descending output," Nature, Nature, vol. 468(7324), pages 686-690, December.
    3. Yael Grosjean & Raphael Rytz & Jean-Pierre Farine & Liliane Abuin & Jérôme Cortot & Gregory S. X. E. Jefferis & Richard Benton, 2011. "An olfactory receptor for food-derived odours promotes male courtship in Drosophila," Nature, Nature, vol. 478(7368), pages 236-240, October.
    4. Amina Kurtovic & Alexandre Widmer & Barry J. Dickson, 2007. "A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone," Nature, Nature, vol. 446(7135), pages 542-546, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Pranjul Singh & Shefali Goyal & Smith Gupta & Sanket Garg & Abhinav Tiwari & Varad Rajput & Alexander Shakeel Bates & Arjit Kant Gupta & Nitin Gupta, 2023. "Combinatorial encoding of odors in the mosquito antennal lobe," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Martin F Strube-Bloss & Austin Brown & Johannes Spaethe & Thomas Schmitt & Wolfgang Rössler, 2015. "Extracting the Behaviorally Relevant Stimulus: Unique Neural Representation of Farnesol, a Component of the Recruitment Pheromone of Bombus terrestris," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-16, September.
    3. Thomas A. Verschut & Renny Ng & Nicolas P. Doubovetzky & Guillaume Calvez & Jan L. Sneep & Adriaan J. Minnaard & Chih-Ying Su & Mikael A. Carlsson & Bregje Wertheim & Jean-Christophe Billeter, 2023. "Aggregation pheromones have a non-linear effect on oviposition behavior in Drosophila melanogaster," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Genevieve C. Jouandet & Michael H. Alpert & José Miguel Simões & Richard Suhendra & Dominic D. Frank & Joshua I. Levy & Alessia Para & William L. Kath & Marco Gallio, 2023. "Rapid threat assessment in the Drosophila thermosensory system," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Javier J How & Saket Navlakha & Sreekanth H Chalasani, 2021. "Neural network features distinguish chemosensory stimuli in Caenorhabditis elegans," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-38, November.
    6. Nan-Ji Jiang & Hetan Chang & Jerrit Weißflog & Franziska Eberl & Daniel Veit & Kerstin Weniger & Bill S. Hansson & Markus Knaden, 2023. "Ozone exposure disrupts insect sexual communication," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    7. David Scott & Alicia Shields & Michaela Straker & Heidi Dalrymple & Priya K Dhillon & Singh Harbinder, 2011. "Variation in the Male Pheromones and Mating Success of Wild Caught Drosophila melanogaster," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-8, August.
    8. Maria E Yurgel & Priyanka Kakad & Meet Zandawala & Dick R Nässel & Tanja A Godenschwege & Alex C Keene, 2019. "A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions," PLOS Biology, Public Library of Science, vol. 17(2), pages 1-26, February.
    9. Rishabh Chandak & Baranidharan Raman, 2023. "Neural manifolds for odor-driven innate and acquired appetitive preferences," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30165-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.