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Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis

Author

Listed:
  • Corina N. D’Alessandro-Gabazza

    (Mie University Faculty and Graduate School of Medicine
    Mie University
    University of Illinois at Urbana–Champaign)

  • Taro Yasuma

    (Mie University Faculty and Graduate School of Medicine
    Mie University Faculty and Graduate School of Medicine)

  • Tetsu Kobayashi

    (Mie University Faculty and Graduate School of Medicine)

  • Masaaki Toda

    (Mie University Faculty and Graduate School of Medicine
    Mie University)

  • Ahmed M. Abdel-Hamid

    (University of Illinois at Urbana–Champaign
    Minia University)

  • Hajime Fujimoto

    (Mie University Faculty and Graduate School of Medicine)

  • Osamu Hataji

    (Matsusaka Municipal Hospital)

  • Hiroki Nakahara

    (Mie University Faculty and Graduate School of Medicine)

  • Atsuro Takeshita

    (Mie University Faculty and Graduate School of Medicine
    Mie University Faculty and Graduate School of Medicine)

  • Kota Nishihama

    (Mie University Faculty and Graduate School of Medicine)

  • Tomohito Okano

    (Mie University Faculty and Graduate School of Medicine)

  • Haruko Saiki

    (Mie University Faculty and Graduate School of Medicine)

  • Yuko Okano

    (Mie University Faculty and Graduate School of Medicine
    Mie University Faculty and Graduate School of Medicine)

  • Atsushi Tomaru

    (Mie University Faculty and Graduate School of Medicine)

  • Valeria Fridman D’Alessandro

    (Mie University Faculty and Graduate School of Medicine)

  • Miyako Shiraishi

    (University of Illinois at Urbana–Champaign)

  • Akira Mizoguchi

    (Mie University Graduate School of Medicine)

  • Ryoichi Ono

    (Mie University Graduate School of Medicine)

  • Junpei Ohtsuka

    (Mie University Graduate School of Medicine
    BioComo Incorporation)

  • Masayuki Fukumura

    (Mie University Graduate School of Medicine
    BioComo Incorporation)

  • Tetsuya Nosaka

    (Mie University Graduate School of Medicine)

  • Xuenan Mi

    (University of Illinois at Urbana-Champaign)

  • Diwakar Shukla

    (University of Illinois at Urbana-Champaign)

  • Kensuke Kataoka

    (Tosei General Hospital)

  • Yasuhiro Kondoh

    (Tosei General Hospital)

  • Masaki Hirose

    (National Hospital Organization Kinki-Chuo Chest Medical Center)

  • Toru Arai

    (National Hospital Organization Kinki-Chuo Chest Medical Center)

  • Yoshikazu Inoue

    (National Hospital Organization Kinki-Chuo Chest Medical Center)

  • Yutaka Yano

    (Mie University Faculty and Graduate School of Medicine)

  • Roderick I. Mackie

    (University of Illinois at Urbana–Champaign
    The University of Illinois at Urbana–Champaign
    the University of Illinois at Urbana–Champaign)

  • Isaac Cann

    (University of Illinois at Urbana–Champaign
    The University of Illinois at Urbana–Champaign
    the University of Illinois at Urbana–Champaign
    The University of Illinois at Urbana–Champaign)

  • Esteban C. Gabazza

    (Mie University Faculty and Graduate School of Medicine
    Mie University
    University of Illinois at Urbana–Champaign)

Abstract

Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute exacerbation of idiopathic pulmonary fibrosis is associated with high mortality. Excessive apoptosis of lung epithelial cells occurs in pulmonary fibrosis acute exacerbation. We recently identified corisin, a proapoptotic peptide that triggers acute exacerbation of pulmonary fibrosis. Here, we provide insights into the mechanism underlying the processing and release of corisin. Furthermore, we demonstrate that an anticorisin monoclonal antibody ameliorates lung fibrosis by significantly inhibiting acute exacerbation in the human transforming growth factorβ1 model and acute lung injury in the bleomycin model. By investigating the impact of the anticorisin monoclonal antibody in a general model of acute lung injury, we further unravel the potential of corisin to impact such diseases. These results underscore the role of corisin in the pathogenesis of acute exacerbation of pulmonary fibrosis and acute lung injury and provide a novel approach to treating this incurable disease.

Suggested Citation

  • Corina N. D’Alessandro-Gabazza & Taro Yasuma & Tetsu Kobayashi & Masaaki Toda & Ahmed M. Abdel-Hamid & Hajime Fujimoto & Osamu Hataji & Hiroki Nakahara & Atsuro Takeshita & Kota Nishihama & Tomohito O, 2022. "Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29064-3
    DOI: 10.1038/s41467-022-29064-3
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    References listed on IDEAS

    as
    1. Corina N. D’Alessandro-Gabazza & Tetsu Kobayashi & Taro Yasuma & Masaaki Toda & Heejin Kim & Hajime Fujimoto & Osamu Hataji & Atsuro Takeshita & Kota Nishihama & Tomohito Okano & Yuko Okano & Yoichi N, 2020. "A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    2. Yuelan Yin & Hao Yao & Swapnil Doijad & Suwei Kong & Yang Shen & Xuexue Cai & Weijun Tan & Yuting Wang & Youwei Feng & Zhiting Ling & Guoliang Wang & Yachen Hu & Kai Lian & Xinyu Sun & Yuliang Liu & C, 2019. "A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    3. Christopher M. Dobson, 2003. "Protein folding and misfolding," Nature, Nature, vol. 426(6968), pages 884-890, December.
    4. Ivana V Yang & Leah G Luna & Jennifer Cotter & Janet Talbert & Sonia M Leach & Raven Kidd & Julia Turner & Nathan Kummer & Dolly Kervitsky & Kevin K Brown & Kathy Boon & Marvin I Schwarz & David A Sch, 2012. "The Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-11, June.
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