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Burdens of post-acute sequelae of COVID-19 by severity of acute infection, demographics and health status

Author

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  • Yan Xie

    (VA Saint Louis Health Care System
    Veterans Research and Education Foundation of Saint Louis
    Saint Louis University)

  • Benjamin Bowe

    (VA Saint Louis Health Care System
    Veterans Research and Education Foundation of Saint Louis
    Saint Louis University)

  • Ziyad Al-Aly

    (VA Saint Louis Health Care System
    Veterans Research and Education Foundation of Saint Louis
    Washington University School of Medicine
    Washington University in Saint Louis)

Abstract

The Post-Acute Sequelae of SARS-CoV-2 infection (PASC) have been characterized; however, the burden of PASC remains unknown. Here we used the healthcare databases of the US Department of Veterans Affairs to build a cohort of 181,384 people with COVID-19 and 4,397,509 non-infected controls and estimated that burden of PASC—defined as the presence of at least one sequela in excess of non-infected controls—was 73.43 (72.10, 74.72) per 1000 persons at 6 months. Burdens of individual sequelae varied by demographic groups (age, race, and sex) but were consistently higher in people with poorer baseline health and in those with more severe acute infection. In sum, the burden of PASC is substantial; PASC is non-monolithic with sequelae that are differentially expressed in various population groups. Collectively, our results may be useful in informing health systems capacity planning and care strategies of people with PASC.

Suggested Citation

  • Yan Xie & Benjamin Bowe & Ziyad Al-Aly, 2021. "Burdens of post-acute sequelae of COVID-19 by severity of acute infection, demographics and health status," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26513-3
    DOI: 10.1038/s41467-021-26513-3
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    References listed on IDEAS

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    1. Ziyad Al-Aly & Yan Xie & Benjamin Bowe, 2021. "High-dimensional characterization of post-acute sequelae of COVID-19," Nature, Nature, vol. 594(7862), pages 259-264, June.
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    1. Rúbens Prince dos Santos Alves & Julia Timis & Robyn Miller & Kristen Valentine & Paolla Beatriz Almeida Pinto & Andrew Gonzalez & Jose Angel Regla-Nava & Erin Maule & Michael N. Nguyen & Norazizah Sh, 2024. "Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Ivan Chun Hang Lam & Ran Zhang & Kenneth Keng Cheung Man & Carlos King Ho Wong & Celine Sze Ling Chui & Francisco Tsz Tsun Lai & Xue Li & Esther Wai Yin Chan & Chak Sing Lau & Ian Chi Kei Wong & Eric , 2024. "Persistence in risk and effect of COVID-19 vaccination on long-term health consequences after SARS-CoV-2 infection," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Chengxi Zang & Yongkang Zhang & Jie Xu & Jiang Bian & Dmitry Morozyuk & Edward J. Schenck & Dhruv Khullar & Anna S. Nordvig & Elizabeth A. Shenkman & Russell L. Rothman & Jason P. Block & Kristin Lyma, 2023. "Data-driven analysis to understand long COVID using electronic health records from the RECOVER initiative," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Aarthi Talla & Suhas V. Vasaikar & Gregory Lee Szeto & Maria P. Lemos & Julie L. Czartoski & Hugh MacMillan & Zoe Moodie & Kristen W. Cohen & Lamar B. Fleming & Zachary Thomson & Lauren Okada & Lynne , 2023. "Persistent serum protein signatures define an inflammatory subcategory of long COVID," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Evan Xu & Yan Xie & Ziyad Al-Aly, 2023. "Long-term gastrointestinal outcomes of COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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