IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-19715-8.html
   My bibliography  Save this article

Neonicotinoid Clothianidin reduces honey bee immune response and contributes to Varroa mite proliferation

Author

Listed:
  • Desiderato Annoscia

    (Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine)

  • Gennaro Di Prisco

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”
    CREA, Consiglio per la Ricerca in Agricoltura e l’Analisi dell’Economia Agraria, Centro di Ricerca Agricoltura e Ambiente)

  • Andrea Becchimanzi

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”)

  • Emilio Caprio

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”)

  • Davide Frizzera

    (Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine)

  • Alberto Linguadoca

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”
    Department of Biological Sciences, Royal Holloway, University of London)

  • Francesco Nazzi

    (Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine)

  • Francesco Pennacchio

    (Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”)

Abstract

The neonicotinoid Clothianidin has a negative impact on NF-κB signaling and on immune responses controlled by this transcription factor, which can boost the proliferation of honey bee parasites and pathogens. This effect has been well documented for the replication of deformed wing virus (DWV) induced by Clothianidin in honey bees bearing an asymptomatic infection. Here, we conduct infestation experiments of treated bees to show that the immune-suppression exerted by Clothianidin is associated with an enhanced fertility of the parasitic mite Varroa destructor, as a possible consequence of a higher feeding efficiency. A conceptual model is proposed to describe the synergistic interactions among different stress agents acting on honey bees.

Suggested Citation

  • Desiderato Annoscia & Gennaro Di Prisco & Andrea Becchimanzi & Emilio Caprio & Davide Frizzera & Alberto Linguadoca & Francesco Nazzi & Francesco Pennacchio, 2020. "Neonicotinoid Clothianidin reduces honey bee immune response and contributes to Varroa mite proliferation," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19715-8
    DOI: 10.1038/s41467-020-19715-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-19715-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-19715-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Agnieszka Murawska & Paweł Migdał & Adam Roman, 2021. "Effects of Plant Protection Products on Biochemical Markers in Honey Bees," Agriculture, MDPI, vol. 11(7), pages 1-14, July.
    2. Dimitri Breda & Davide Frizzera & Giulia Giordano & Elisa Seffin & Virginia Zanni & Desiderato Annoscia & Christopher J. Topping & Franco Blanchini & Francesco Nazzi, 2022. "A deeper understanding of system interactions can explain contradictory field results on pesticide impact on honey bees," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Yinying Yang & Yuzheng Wu & Hexuan Long & Xuelin Ma & Kaavian Shariati & James Webb & Liang Guo & Yang Pan & Minglin Ma & Chao Deng & Peng Cao & Jing Chen, 2023. "Global honeybee health decline factors and potential conservation techniques," Food Security: The Science, Sociology and Economics of Food Production and Access to Food, Springer;The International Society for Plant Pathology, vol. 15(4), pages 855-875, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19715-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.