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Programmed magnetic manipulation of vesicles into spatially coded prototissue architectures arrays

Author

Listed:
  • Qingchuan Li

    (Harbin Institute of Technology)

  • Shubin Li

    (Harbin Institute of Technology)

  • Xiangxiang Zhang

    (Harbin Institute of Technology)

  • Weili Xu

    (Harbin Institute of Technology)

  • Xiaojun Han

    (Harbin Institute of Technology)

Abstract

In nature, cells self-assemble into spatially coded tissular configurations to execute higher-order biological functions as a collective. This mechanism has stimulated the recent trend in synthetic biology to construct tissue-like assemblies from protocell entities, with the aim to understand the evolution mechanism of multicellular mechanisms, create smart materials or devices, and engineer tissue-like biomedical implant. However, the formation of spatially coded and communicating micro-architectures from large quantity of protocell entities, especially for lipid vesicle-based systems that mostly resemble cells, is still challenging. Herein, we magnetically assemble giant unilamellar vesicles (GUVs) or cells into various microstructures with spatially coded configurations and spatialized cascade biochemical reactions using a stainless steel mesh. GUVs in these tissue-like aggregates exhibit uncustomary osmotic stability that cannot be achieved by individual GUVs suspensions. This work provides a versatile and cost-effective strategy to form robust tissue-mimics and indicates a possible superiority of protocell colonies to individual protocells.

Suggested Citation

  • Qingchuan Li & Shubin Li & Xiangxiang Zhang & Weili Xu & Xiaojun Han, 2020. "Programmed magnetic manipulation of vesicles into spatially coded prototissue architectures arrays," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14141-x
    DOI: 10.1038/s41467-019-14141-x
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    Cited by:

    1. Xiangxiang Zhang & Chao Li & Fukai Liu & Wei Mu & Yongshuo Ren & Boyu Yang & Xiaojun Han, 2022. "High-throughput production of functional prototissues capable of producing NO for vasodilation," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Jorik Waeterschoot & Willemien Gosselé & Špela Lemež & Xavier Casadevall i Solvas, 2024. "Artificial cells for in vivo biomedical applications through red blood cell biomimicry," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Songyang Liu & Yanwen Zhang & Xiaoxiao He & Mei Li & Jin Huang & Xiaohai Yang & Kemin Wang & Stephen Mann & Jianbo Liu, 2022. "Signal processing and generation of bioactive nitric oxide in a model prototissue," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Nishkantha Arulkumaran & Mervyn Singer & Stefan Howorka & Jonathan R. Burns, 2023. "Creating complex protocells and prototissues using simple DNA building blocks," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Jin Li & William D. Jamieson & Pantelitsa Dimitriou & Wen Xu & Paul Rohde & Boris Martinac & Matthew Baker & Bruce W. Drinkwater & Oliver K. Castell & David A. Barrow, 2022. "Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Shubin Li & Yingming Zhao & Shuqi Wu & Xiangxiang Zhang & Boyu Yang & Liangfei Tian & Xiaojun Han, 2023. "Regulation of species metabolism in synthetic community systems by environmental pH oscillations," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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