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Multi-cohort study identifies social determinants of systemic inflammation over the life course

Author

Listed:
  • Eloïse Berger

    (Inserm-Université Toulouse III Paul Sabatier)

  • Raphaële Castagné

    (Inserm-Université Toulouse III Paul Sabatier)

  • Marc Chadeau-Hyam

    (Imperial College London)

  • Murielle Bochud

    (Lausanne University Hospital)

  • Angelo d’Errico

    (ASL TO3 Piedmont Region)

  • Martina Gandini

    (ASL TO3 Piedmont Region)

  • Maryam Karimi

    (Imperial College London)

  • Mika Kivimäki

    (University College London
    University of Helsinki)

  • Vittorio Krogh

    (Fondazione IRCCS Istituto Nazionale dei Tumori)

  • Michael Marmot

    (University College London)

  • Salvatore Panico

    (University of Naples Federico II)

  • Martin Preisig

    (Lausanne University Hospital)

  • Fulvio Ricceri

    (ASL TO3 Piedmont Region)

  • Carlotta Sacerdote

    (Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte))

  • Andrew Steptoe

    (University College London)

  • Silvia Stringhini

    (Lausanne University Hospital)

  • Rosario Tumino

    (‘Civic – M. P. Arezzo’ Hospital, ASP Ragusa)

  • Paolo Vineis

    (Imperial College London
    Italian Institute for Genomic Medicine (IIGM))

  • Cyrille Delpierre

    (Inserm-Université Toulouse III Paul Sabatier)

  • Michelle Kelly-Irving

    (Inserm-Université Toulouse III Paul Sabatier)

Abstract

Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. We find a consistent inverse association between SEP and CRP across cohorts, where participants with a less advantaged SEP have higher levels of inflammation. Educational attainment is most strongly related to inflammation, after adjusting for health behaviours, body mass index and later-in-life SEP. These findings suggest socioeconomic disadvantage in young adulthood is independently associated with later life inflammation calling for further studies of the pathways operating through educational processes.

Suggested Citation

  • Eloïse Berger & Raphaële Castagné & Marc Chadeau-Hyam & Murielle Bochud & Angelo d’Errico & Martina Gandini & Maryam Karimi & Mika Kivimäki & Vittorio Krogh & Michael Marmot & Salvatore Panico & Marti, 2019. "Multi-cohort study identifies social determinants of systemic inflammation over the life course," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08732-x
    DOI: 10.1038/s41467-019-08732-x
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    Cited by:

    1. Vineis, Paolo & Delpierre, Cyrille & Castagné, Raphaële & Fiorito, Giovanni & McCrory, Cathal & Kivimaki, Mika & Stringhini, Silvia & Carmeli, Cristian & Kelly-Irving, Michelle, 2020. "Health inequalities: Embodied evidence across biological layers," Social Science & Medicine, Elsevier, vol. 246(C).
    2. Oberndorfer, Moritz & Leyland, Alastair H. & Pearce, Jamie & Grabovac, Igor & Hannah, Mary K. & Dorner, Thomas E., 2023. "Unequally Unequal? Contextual-level status inequality and social cohesion moderating the association between individual-level socioeconomic position and systemic chronic inflammation," Social Science & Medicine, Elsevier, vol. 333(C).
    3. Slagboom, M. Nienke & Crone, Mathilde R. & Reis, Ria, 2022. "Exploring syndemic vulnerability across generations: A case study of a former fishing village in the Netherlands," Social Science & Medicine, Elsevier, vol. 295(C).
    4. Kim, Hwang, 2021. "COVID-19 Apps as a Digital Intervention Policy: A Longitudinal Panel Data Analysis in South Korea," Health Policy, Elsevier, vol. 125(11), pages 1430-1440.

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