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Changes in the Gut Microbiome and Pathologies in Pregnancy

Author

Listed:
  • Kamila Gorczyca

    (Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland)

  • Aleksandra Obuchowska

    (Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland)

  • Żaneta Kimber-Trojnar

    (Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland)

  • Magdalena Wierzchowska-Opoka

    (Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland)

  • Bożena Leszczyńska-Gorzelak

    (Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland)

Abstract

Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregnancy. There is an increase in Akkermansia, Bifidobacterium, and Firmicutes, which have been associated with an increase in the need for energy storage. The growth in Proteobacteria and Actinobacteria levels has a protective effect on both the mother and the fetus via proinflammatory mechanisms. The aim of the study is to review the research on the relationship between the mother’s intestinal microbiome and gestational pathologies. Changes in the maternal gut microbiome is probably one of the mechanisms that occurs in various pregnancy diseases such as preeclampsia, fetal growth restriction, gestational diabetes mellitus, excessive gestational weight gain, and premature birth. For this reason, it seems vital to pay attention to certain interventions that can benefit the affected patients both in the short term, by preventing complications during pregnancy, and in the long term, as one of the mechanisms occurring in various gestational diseases is dysbiosis of the maternal intestinal flora.

Suggested Citation

  • Kamila Gorczyca & Aleksandra Obuchowska & Żaneta Kimber-Trojnar & Magdalena Wierzchowska-Opoka & Bożena Leszczyńska-Gorzelak, 2022. "Changes in the Gut Microbiome and Pathologies in Pregnancy," IJERPH, MDPI, vol. 19(16), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:9961-:d:886830
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    1. Yukihiro Furusawa & Yuuki Obata & Shinji Fukuda & Takaho A. Endo & Gaku Nakato & Daisuke Takahashi & Yumiko Nakanishi & Chikako Uetake & Keiko Kato & Tamotsu Kato & Masumi Takahashi & Noriko N. Fukuda, 2013. "Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells," Nature, Nature, vol. 504(7480), pages 446-450, December.
    2. Arihiro Shiozaki & Satoshi Yoneda & Noriko Yoneda & Rika Yonezawa & Takamichi Matsubayashi & Genichiro Seo & Shigeru Saito, 2014. "Intestinal Microbiota is Different in Women with Preterm Birth: Results from Terminal Restriction Fragment Length Polymorphism Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-1, November.
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