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Characterization of Clinical Features of Hospitalized Patients Due to the SARS-CoV-2 Infection in the Absence of Comorbidities Regarding the Sex: An Epidemiological Study of the First Year of the Pandemic in Brazil

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  • Nathália Mariana Santos Sansone

    (Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil
    Laboratory of Human and Medical Genetics, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil
    These authors contributed equally to this study.)

  • Letícia Rogini Pereira

    (Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil
    Laboratory of Human and Medical Genetics, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil
    These authors contributed equally to this study.)

  • Matheus Negri Boschiero

    (Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil
    Laboratory of Human and Medical Genetics, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil)

  • Felipe Eduardo Valencise

    (Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil
    Laboratory of Human and Medical Genetics, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil)

  • Andréa Melo Alexandre Fraga

    (Department of Pediatrics, University of Campinas, Campinas, São Paulo 13083-887, Brazil)

  • Fernando Augusto Lima Marson

    (Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil
    Laboratory of Human and Medical Genetics, University of São Francisco, Bragança Paulista, São Paulo 12916-9003, Brazil
    These authors contributed equally to this study.)

Abstract

The male sex, due to the presence of genetic, immunological, hormonal, social, and environmental factors, is associated with higher severity and death in Coronavirus Disease (COVID)-19. We conducted an epidemiological study to characterize the COVID-19 clinical profile, severity, and outcome according to sex in patients with the severe acute respiratory syndrome (SARS) due to the fact of this disease. We carried out an epidemiological analysis using epidemiological data made available by the OpenDataSUS, which stores information about SARS in Brazil. We recorded the features of the patients admitted to the hospital for SARS treatment due to the presence of COVID-19 (in the absence of comorbidities) and associated these characteristics with sex and risk of death. The study comprised 336,463 patients, 213,151 of whom were men. Male patients presented a higher number of clinical signs, for example, fever (OR = 1.424; 95%CI = 1.399–1.448), peripheral arterial oxygen saturation (SpO 2 ) < 95% (OR = 1.253; 95%CI = 1.232–1.274), and dyspnea (OR = 1.146; 95%CI = 1.125–1.166) as well as greater need for admission in intensive care unit (ICU, OR = 1.189; 95%CI = 1.168–1.210), and the use of invasive ventilatory support (OR = 1.306; 95%CI = 1.273–1.339) and noninvasive ventilatory support (OR = 1.238; 95%CI = 1.216–1.260) when compared with female patients. Curiously, the male sex was associated only with a small increase in the risk of death when compared with the female sex (OR = 1.041; 95%CI = 1.023–1.060). We did a secondary analysis to identify the main predictors of death. In that sense, the multivariate analysis enabled the prediction of the risk of death, and the male sex was one of the predictors (OR = 1.101; 95%CI = 1.011–1.199); however, with a small effect size. In addition, other factors also contributed to this prediction and presented a great effect size, they are listed below: older age (61–72 years old (OR = 15.778; 95%CI = 1.865–133.492), 73–85 years old (OR = 31.978; 95%CI = 3.779–270.600), and +85 years old (OR = 68.385; 95%CI = 8.164–589.705)); race (Black (OR = 1.247; 95%CI = 1.016–1.531), Pardos (multiracial background; OR = 1.585; 95%CI = 1.450–1.732), and Indigenous (OR = 3.186; 95%CI = 1.927–5.266)); clinical signs (for instance, dyspnea (OR = 1.231; 95%CI = 1.110–1.365) and SpO 2 < 95% (OR = 1.367; 95%CI = 1.238–1.508)); need for admission in the ICU (OR = 3.069; 95%CI = 2.789–3.377); and for ventilatory support (invasive (OR = 10.174; 95%CI = 8.803–11.759) and noninvasive (OR = 1.609; 95%CI = 1.438–1.800)). In conclusion, in Brazil, male patients tend to present the phenotype of higher severity in COVID-19, however, with a small effect on the risk of death.

Suggested Citation

  • Nathália Mariana Santos Sansone & Letícia Rogini Pereira & Matheus Negri Boschiero & Felipe Eduardo Valencise & Andréa Melo Alexandre Fraga & Fernando Augusto Lima Marson, 2022. "Characterization of Clinical Features of Hospitalized Patients Due to the SARS-CoV-2 Infection in the Absence of Comorbidities Regarding the Sex: An Epidemiological Study of the First Year of the Pand," IJERPH, MDPI, vol. 19(15), pages 1-20, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:8895-:d:868720
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    1. Takehiro Takahashi & Mallory K. Ellingson & Patrick Wong & Benjamin Israelow & Carolina Lucas & Jon Klein & Julio Silva & Tianyang Mao & Ji Eun Oh & Maria Tokuyama & Peiwen Lu & Arvind Venkataraman & , 2020. "Sex differences in immune responses that underlie COVID-19 disease outcomes," Nature, Nature, vol. 588(7837), pages 315-320, December.
    2. Hannah Peckham & Nina M. Gruijter & Charles Raine & Anna Radziszewska & Coziana Ciurtin & Lucy R. Wedderburn & Elizabeth C. Rosser & Kate Webb & Claire T. Deakin, 2020. "Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    3. Green, Carla A & Pope, Clyde R, 1999. "Gender, psychosocial factors and the use of medical services: a longitudinal analysis," Social Science & Medicine, Elsevier, vol. 48(10), pages 1363-1372, May.
    4. Danielsen, Ann Caroline & Lee, Katharine MN & Boulicault, Marion & Rushovich, Tamara & Gompers, Annika & Tarrant, Amelia & Reiches, Meredith & Shattuck-Heidorn, Heather & Miratrix, Luke W. & Richardso, 2022. "Sex disparities in COVID-19 outcomes in the United States: Quantifying and contextualizing variation," Social Science & Medicine, Elsevier, vol. 294(C).
    5. Richard Rogers & Bethany Everett & Jarron Onge & Patrick Krueger, 2010. "Social, behavioral, and biological factors, and sex differences in mortality," Demography, Springer;Population Association of America (PAA), vol. 47(3), pages 555-578, August.
    6. Taru Tukiainen & Alexandra-Chloé Villani & Angela Yen & Manuel A. Rivas & Jamie L. Marshall & Rahul Satija & Matt Aguirre & Laura Gauthier & Mark Fleharty & Andrew Kirby & Beryl B. Cummings & Stephane, 2017. "Landscape of X chromosome inactivation across human tissues," Nature, Nature, vol. 550(7675), pages 244-248, October.
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