IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i14p8862-d868210.html
   My bibliography  Save this article

Association between Leptin (G2548A) and Leptin Receptor (Q223R) Polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University

Author

Listed:
  • Jaiprakash Mohanraj

    (Department of Biochemistry, School of Medicine, International Medical University, Kuala Lumpur 57000, Malaysia
    Faculty of Medicine & Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu 88400, Malaysia)

  • Urban J. A. D’Souza

    (Department of Physiology, Father Muller College of Allied Health Sciences, Father Muller Medical College, Mangalore 575002, India)

  • Siat Yee Fong

    (Faculty of Medicine & Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu 88400, Malaysia)

  • Ivan Rolland Karkada

    (Department of Physiology, Faculty of Medicine, MAHSA Universiti, Jenjarom 42610, Malaysia)

  • Heethal Jaiprakash

    (Department of Pharmacology, School of Medicine, International Medical University, Kuala Lumpur 57000, Malaysia)

Abstract

Relative leptin resistance in childhood to absolute leptin resistance in maturity suggests sleep, eating behaviour, and the psychological state as probable causes. The current body of research provides inconclusive evidence linking G2548A and Q223R to obesity. Furthermore, we could find very little data that have observed the association between the environment and gene polymorphism, especially in the multiethnic population that exists in Malaysia. This study searched for a possible link between sleeping habits, eating behaviour, and stress indicators with plasma leptin and its genetic variation in young adult Malaysian healthcare students. The study involved 185 first- and second-year medical and dental students from a healthcare university. Polymerase Chain Reaction–Restriction Fragment Length Polymorphism(PCR-RFLP) determined the genotype, Enzyme Linked Immunoabsorbant Assay (ELISA) tested the serum leptin, and a self-administered questionnaire evaluated sleep, eating behaviour, and psychological condition. Gender and ethnicity are linked to fasting plasma leptin levels (p < 0.001). Plasma leptin also affects stress, anxiety, and sadness. Leptin ( LEP ) and Leptin Receptor ( LEPR ) polymorphisms were not associated with BMI, plasma leptin, sleep, eating behaviour, or psychological state. Young adult Malaysian Indians were obese and overweight, while Chinese were underweight. These findings imply overweight and obese participants were in stage I of leptin resistance and lifestyle change or leptin therapy could prevent them from becoming cripplingly obese as they age.

Suggested Citation

  • Jaiprakash Mohanraj & Urban J. A. D’Souza & Siat Yee Fong & Ivan Rolland Karkada & Heethal Jaiprakash, 2022. "Association between Leptin (G2548A) and Leptin Receptor (Q223R) Polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a H," IJERPH, MDPI, vol. 19(14), pages 1-17, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8862-:d:868210
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/14/8862/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/14/8862/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Chaisiri Angkurawaranon & Wichuda Jiraporncharoen & Boriboon Chenthanakij & Pat Doyle & Dorothea Nitsch, 2014. "Urban Environments and Obesity in Southeast Asia: A Systematic Review, Meta-Analysis and Meta-Regression," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-19, November.
    2. Daniel J Corsi & Jocelyn E Finlay & S V Subramanian, 2011. "Global Burden of Double Malnutrition: Has Anyone Seen It?," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-13, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Colette Cunningham-Myrie & Katherine P Theall & Novie Younger-Coleman & Lisa-Gaye Greene & Parris Lyew-Ayee & Rainford Wilks, 2021. "Associations of neighborhood physical and crime environments with obesity-related outcomes in Jamaica," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-19, April.
    2. Ana Cristina Lindsay & Somporn Sitthisongkram & Mary L. Greaney & Sherrie F. Wallington & Praewrapee Ruengdej, 2017. "Non-Responsive Feeding Practices, Unhealthy Eating Behaviors, and Risk of Child Overweight and Obesity in Southeast Asia: A Systematic Review," IJERPH, MDPI, vol. 14(4), pages 1-18, April.
    3. Madhavi Bhargava & Anurag Bhargava & Sudeep D Ghate & R Shyama Prasad Rao, 2020. "Nutritional status of Indian adolescents (15-19 years) from National Family Health Surveys 3 and 4: Revised estimates using WHO 2007 Growth reference," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-24, June.
    4. Cheng Chen & Xianglong Xu & Yan Yan, 2018. "Estimated global overweight and obesity burden in pregnant women based on panel data model," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-14, August.
    5. Małgorzata Ewa Drywień & Jadwiga Hamulka & Monika A. Zielinska-Pukos & Marta Jeruszka-Bielak & Magdalena Górnicka, 2020. "The COVID-19 Pandemic Lockdowns and Changes in Body Weight among Polish Women. A Cross-Sectional Online Survey PLifeCOVID-19 Study," Sustainability, MDPI, vol. 12(18), pages 1-18, September.
    6. Md Mobarak Hossain Khan & Arina Zanuzdana & Alexander Kraemer, 2013. "Levels, Trends and Disparities in Public-Health-Related Indicators among Reproductive-Age Women in Bangladesh by Urban-Rural and Richest-Poorest Groups, 1993-2011," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    7. Madjid Atek & Pierre Traissac & Jalila El Ati & Youcef Laid & Hajer Aounallah-Skhiri & Sabrina Eymard-Duvernay & Nadia Mézimèche & Souha Bougatef & Chiraz Béji & Leila Boutekdjiret & Yves Martin-Préve, 2013. "Obesity and Association with Area of Residence, Gender and Socio-Economic Factors in Algerian and Tunisian Adults," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-10, October.
    8. Asibul Islam Anik & Md Mosfequr Rahman & Md Mostafizur Rahman & Md Ismail Tareque & Md Nuruzzaman Khan & M Mahmudul Alam, 2019. "Double burden of malnutrition at household level: A comparative study among Bangladesh, Nepal, Pakistan, and Myanmar," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-16, August.
    9. Rajat Das Gupta & Shams Shabab Haider & Sumaiya Zabin Eusufzai & Ehsanul Hoque Apu & Nazeeba Siddika, 2022. "Differences in Prevalence and Associated Factors of Underweight and Overweight/Obesity among Bangladeshi Adults by Gender: Analysis of a Nationally Representative Survey," IJERPH, MDPI, vol. 19(17), pages 1-10, August.
    10. Vani S. Kulkarni & Veena S. Kulkarni & Raghav Gaiha, 2013. "Double burden of malnutrition: Why are Indian women likely to be underweight and obese?," Global Development Institute Working Paper Series 19013, GDI, The University of Manchester.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8862-:d:868210. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.