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Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis

Author

Listed:
  • Valentina Flores

    (Program of Master in Dental Sciences, Universidad de La Frontera, Temuco 4780000, Chile)

  • Bernardo Venegas

    (Department of Stomatology, Faculty of Health Sciences, Universidad de Talca, Talca 3460000, Chile)

  • Wendy Donoso

    (Department of Stomatology, Faculty of Health Sciences, Universidad de Talca, Talca 3460000, Chile)

  • Camilo Ulloa

    (Department of Surgical Stomatology, Postgraduate Program in Periodontology, School of Dentistry, Universidad de Concepción, Concepción 4070386, Chile)

  • Alejandra Chaparro

    (Department of Oral Pathology and Conservative Dentistry, Faculty of Dentistry, Universidad de Los Andes, Santiago 7620001, Chile)

  • Vanessa Sousa

    (Periodontology and Periodontal Medicine, Center for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, Guy’s Hospital, London SE1 9RT, UK)

  • Víctor Beltrán

    (Program of Master in Dental Sciences, Universidad de La Frontera, Temuco 4780000, Chile
    Clinical Investigation and Dental Innovation Center (CIDIC), Dental School and Center for Translational Medicine (CEMT-BIOREN), Universidad de La Frontera, Temuco 4780000, Chile)

Abstract

Currently, researchers are focused on the study of cytokines as predictive biomarkers of peri-implantitis (PI) in order to obtain an early diagnosis and prognosis, and for treatment of the disease. The aim of the study was to characterize the peri-implant soft and hard tissues in patients with a peri-implantitis diagnosis. A descriptive observational study was conducted. Fifteen soft tissue (ST) samples and six peri-implant bone tissue (BT) samples were obtained from 13 patients who were diagnosed with peri-implantitis. All the samples were processed and embedded in paraffin for histological and immunohistochemical analyses. A descriptive and quantitative analysis of mast cells and osteocytes, A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF), osteonectin (ON), and ∝-smooth muscle actin (∝-SMA) was performed. We observed the presence of mast cells in peri-implant soft tissue in all samples (mean 9.21 number of mast cells) and osteocytes in peri-implant hard tissue in all samples (mean 37.17 number of osteocytes). The expression of APRIL-ST was 32.17% ± 6.39%, and that of APRIL-BT was 7.09% ± 5.94%. The BAFF-ST expression was 17.26 ± 12.90%, and the BAFF-BT was 12.16% ± 6.30%. The mean percentage of ON was 7.93% ± 3.79%, and ∝-SMA was 1.78% ± 3.79%. It was concluded that the expression of APRIL and BAFF suggests their involvement in the bone resorption observed in peri-implantitis. The lower expression of osteonectin in the peri-implant bone tissue can also be associated with a deficiency in the regulation of bone remodeling and the consequent peri-implant bone loss.

Suggested Citation

  • Valentina Flores & Bernardo Venegas & Wendy Donoso & Camilo Ulloa & Alejandra Chaparro & Vanessa Sousa & Víctor Beltrán, 2022. "Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis," IJERPH, MDPI, vol. 19(14), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8388-:d:858977
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    References listed on IDEAS

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    1. Ladan Jamshidy & Santosh Kumar Tadakamadla & Parsia Choubsaz & Masoud Sadeghi & Jyothi Tadakamadla, 2021. "Association of IL-10 and TNF-α Polymorphisms with Dental Peri-Implant Disease Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis," IJERPH, MDPI, vol. 18(14), pages 1-18, July.
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