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Association of IL-10 and TNF-α Polymorphisms with Dental Peri-Implant Disease Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

Author

Listed:
  • Ladan Jamshidy

    (Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran)

  • Santosh Kumar Tadakamadla

    (School of Medicine and Dentistry & Menzies Health Institute Queensland, Griffith University, Brisbane, QLD 4222, Australia)

  • Parsia Choubsaz

    (Department of Prosthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran)

  • Masoud Sadeghi

    (Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran)

  • Jyothi Tadakamadla

    (School of Medicine and Dentistry, Griffith University, Brisbane, QLD 4222, Australia)

Abstract

Genetic susceptibility has been reported to be an important risk factor for peri-implant disease (PID). The aim of this meta-analysis was to assess the association between TNF-α and IL-10 polymorphisms and PID susceptibility. The Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases were searched for studies published until 12 April 2021. RevMan 5.3, CMA 2.0, SPSS 22.0, and trial sequential analysis software were used. Twelve studies were included in our analysis. The pooled ORs for the association of TNF-α (−308 G > A) , IL-10 (−1082 A > G) , IL-10 (−819 C > T) , and IL-10 (−592 A > C) polymorphisms were 1.12, 0.93, 1.35, and 0.77 for allelic; 1.42, 0.95, 3.41, and 0.34 for homozygous; 1.19, 1.88, 1.23, and 0.49 for heterozygous, 1.53, 1.12, 1.41, and 0.39 for recessive; and 1.16, 1.87, 2.65, and 0.75 for dominant models, respectively, with all the estimates being insignificant. The results showed an association between TNF-α (−308 G > A) polymorphism and the risk of PID in patients of Asian ethnicity (OR = 1.59; p = 0.03). The present meta-analysis illustrated that TNF-α (−308 G > A) , IL-10 (−1082 A > G) , IL-10 (−819 C > T) , and IL-10 (−592 A > C ) polymorphisms were not associated with the risk of PID, whereas TNF-α (−308 G > A) polymorphism was associated with an elevated risk of PID in Asian patients.

Suggested Citation

  • Ladan Jamshidy & Santosh Kumar Tadakamadla & Parsia Choubsaz & Masoud Sadeghi & Jyothi Tadakamadla, 2021. "Association of IL-10 and TNF-α Polymorphisms with Dental Peri-Implant Disease Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis," IJERPH, MDPI, vol. 18(14), pages 1-18, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7697-:d:597648
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    Cited by:

    1. Valentina Flores & Bernardo Venegas & Wendy Donoso & Camilo Ulloa & Alejandra Chaparro & Vanessa Sousa & Víctor Beltrán, 2022. "Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis," IJERPH, MDPI, vol. 19(14), pages 1-9, July.

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