IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i17p9111-d624519.html
   My bibliography  Save this article

Cardiovascular Disease and Chronic Endodontic Infection. Is There an Association? A Systematic Review and Meta-Analysis

Author

Listed:
  • Despina Koletsi

    (Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, CH-8032 Zurich, Switzerland)

  • Anna Iliadi

    (Department of Dental Biomaterials, School of Dentistry, National and Kapodistrian University of Athens, 10679 Athens, Greece)

  • Giorgos N. Tzanetakis

    (Department of Endodontics, School of Dentistry, National and Kapodistrian University of Athens, 10679 Athens, Greece)

  • Manolis Vavuranakis

    (First Cardiology Department, National and Kapodistrian University of Athens, Hippocration Hospital, 10679 Athens, Greece)

  • Theodore Eliades

    (Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, CH-8032 Zurich, Switzerland)

Abstract

The aim of the present study was to systematically assess existing evidence on the possible association between chronic endodontic infections and cardiovascular disease (CVD). An electronic database search was implemented until 2 October 2020. The main outcome was risk of CVD diagnosis. Risk of bias was assessed through the ROBINS-I tool, while random effects meta-analyses were conducted. The quality of the evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation. Twenty-one studies were eligible for inclusion, while 10 were included in the quantitative synthesis. Risk for CVD diagnosis in patients with chronic endodontic infection was 1.38 times those without infection (RR = 1.38; 95% CIs: 1.06, 1.80; p = 0.008). Risk of bias ranged from moderate to serious, while the quality of the evidence was graded as very low. Indications for an identified association between chronic endodontic infection and CVDs do exist; however, they are not grounded on high-quality evidence at present. Further research for an establishment of an association based on temporal sequence of the two entities and on unbiased well-conducted cohort studies would be highly valued.

Suggested Citation

  • Despina Koletsi & Anna Iliadi & Giorgos N. Tzanetakis & Manolis Vavuranakis & Theodore Eliades, 2021. "Cardiovascular Disease and Chronic Endodontic Infection. Is There an Association? A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(17), pages 1-18, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:17:p:9111-:d:624519
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/17/9111/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/17/9111/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Padhraig S Fleming & Despina Koletsi & Nikolaos Pandis, 2014. "Blinded by PRISMA: Are Systematic Reviewers Focusing on PRISMA and Ignoring Other Guidelines?," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Seo, Chunghyeon & Kim, Bitna & Kruis, Nathan E., 2021. "Variation across police response models for handling encounters with people with mental illnesses: A systematic review and meta-analysis," Journal of Criminal Justice, Elsevier, vol. 72(C).
    2. Kim, Bitna, 2022. "Publication bias: A “bird's-eye view” of meta-analytic practice in criminology and criminal justice," Journal of Criminal Justice, Elsevier, vol. 78(C).
    3. Emilio Abad-Segura & Mariana-Daniela González-Zamar & Antonio Luque-de la Rosa & María Belén Morales Cevallos, 2020. "Sustainability of Educational Technologies: An Approach to Augmented Reality Research," Sustainability, MDPI, vol. 12(10), pages 1-28, May.
    4. Hisham Abusaada & Abeer Elshater, 2022. "Notes on Developing Research Review in Urban Planning and Urban Design Based on PRISMA Statement," Social Sciences, MDPI, vol. 11(9), pages 1-8, August.
    5. Marialuisa Saviano & Sergio Barile & Francesco Caputo & Mattia Lettieri & Stefania Zanda, 2019. "From Rare to Neglected Diseases: A Sustainable and Inclusive Healthcare Perspective for Reframing the Orphan Drugs Issue," Sustainability, MDPI, vol. 11(5), pages 1-21, March.
    6. Abeer Elshater & Hisham Abusaada, 2022. "Developing Process for Selecting Research Techniques in Urban Planning and Urban Design with a PRISMA-Compliant Review," Social Sciences, MDPI, vol. 11(10), pages 1-17, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:17:p:9111-:d:624519. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.