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Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly

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  • Tzu-Chueh Wang

    (Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan)

  • Pou-Jen Ku

    (Taiwan Pharmacist Association, Taipei City 10452, Taiwan)

  • Hai-Lin Lu

    (Department of Information Management, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan)

  • Kung-Chuan Hsu

    (Giraffe Pharmacy, Tainan City 71049, Taiwan)

  • Damien Trezise

    (Department of Applied Foreign Languages, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan)

  • Hue-Yu Wang

    (Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan
    Department of Pharmacy, Chi-Mei Medical Center, Tainan City 71004, Taiwan)

Abstract

Long-term continuous exposure to potentially inappropriate medications (PIMs) can lead to adverse events in the elderly. However, the effects of long-term exposure of the elderly to PIM and the relationship between PIM and chronic diseases remain unclear. The objective of this study was to investigate the continuous use of PIMs in a community-dwelling elderly population. A cross-sectional population-based study was conducted using community pharmacy–filed dispensing records from the Hcare system. Twenty-three community pharmacies were sampled from 2013 to 2015 to obtain records of patients above 65 years-old with continuous prescriptions. PIM were identified according to the 2015 Beers Criteria. The prevalence of patients using PIM was highest in patients with co-morbid mental disorders (40.05%), followed by neurological system disorders (28.91%). Patients who were prescribed a PIM were more than three times as likely to have a mental disorder as those (odds ratio 3.16, 95% confidence interval: 3.06–3.28) with non-chronic diseases. The most prescribed PIM agents were central nervous system drugs (53.16%), and benzodiazepines (35.15%). Patients with mental disorders had the highest rate of long-term persistent PIM exposure, with benzodiazepines being the most frequently dispensed. Drug safety concerns should be closely monitored in elderly patients with the abovementioned conditions.

Suggested Citation

  • Tzu-Chueh Wang & Pou-Jen Ku & Hai-Lin Lu & Kung-Chuan Hsu & Damien Trezise & Hue-Yu Wang, 2019. "Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly," IJERPH, MDPI, vol. 16(12), pages 1-12, June.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:12:p:2189-:d:241717
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    References listed on IDEAS

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    1. Oliver Reich & Thomas Rosemann & Roland Rapold & Eva Blozik & Oliver Senn, 2014. "Potentially Inappropriate Medication Use in Older Patients in Swiss Managed Care Plans: Prevalence, Determinants and Association with Hospitalization," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-9, August.
    2. Marengoni, A. & Winblad, B. & Karp, A. & Fratiglioni, L., 2008. "Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden," American Journal of Public Health, American Public Health Association, vol. 98(7), pages 1198-1200.
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    1. Teen-Hang Meen & Yusuke Matsumoto & Kuei-Shu Hsu, 2020. "Selected Papers from 2019 IEEE Eurasia Conference on Biomedical Engineering, Healthcare and Sustainability (IEEE ECBIOS 2019)," IJERPH, MDPI, vol. 17(8), pages 1-4, April.
    2. Kyungwon Yoon & Jung-Tae Kim & Won-Gun Kwack & Donghyun Kim & Kyung-Tae Lee & Seungwon Yang & Sangmin Lee & Yeo-Jin Choi & Eun-Kyoung Chung, 2022. "Potentially Inappropriate Medication Use in Patients with Dementia," IJERPH, MDPI, vol. 19(18), pages 1-12, September.
    3. Kung-Chuan Hsu & Hai-Lin Lu & Chi-Ming Kuan & Jin-Song Wu & Chyn-Liang Huang & Pu-Hua Lin & Damien Trezise & Tzu-Chueh Wang, 2021. "Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services," IJERPH, MDPI, vol. 18(3), pages 1-11, January.
    4. Motoyasu Miyazaki & Masanobu Uchiyama & Yoshihiko Nakamura & Koichi Matsuo & Chika Ono & Miwa Goto & Ayako Unoki & Akio Nakashima & Osamu Imakyure, 2020. "Association of Self-Reported Medication Adherence with Potentially Inappropriate Medications in Elderly Patients: A Cross-Sectional Pilot Study," IJERPH, MDPI, vol. 17(16), pages 1-13, August.

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