IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i12p2860-d190608.html
   My bibliography  Save this article

Association of Exposure to Fine-Particulate Air Pollution and Acidic Gases with Incidence of Nephrotic Syndrome

Author

Listed:
  • Shih-Yi Lin

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan
    Division of Nephrology and Kidney Institute, China Medical University Hospital, 404 Taichung, Taiwan)

  • Wu-Huei Hsu

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan
    Department of Chest Medicine, China Medical University Hospital, 404 Taichung, Taiwan)

  • Cheng-Li Lin

    (Management Office for Health Data, China Medical University Hospital, 404 Taichung, Taiwan
    College of Medicine, China Medical University, 404 Taichung, Taiwan)

  • Cheng-Chieh Lin

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan
    Department of Family Medicine, China Medical University Hospital, 404 Taichung, Taiwan)

  • Chih-Hsueh Lin

    (Department of Geriatrics, China Medical University Hospital, 404 Taichung, Taiwan)

  • I-Kuan Wang

    (Division of Nephrology and Kidney Institute, China Medical University Hospital, 404 Taichung, Taiwan)

  • Chung-Y. Hsu

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan)

  • Chia-Hung Kao

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan
    Department of Nuclear Medicine and PET Center, China Medical University Hospital, 404 Taichung, Taiwan
    Department of Bioinformatics and Medical Engineering, Asia University, 413 Taichung, Taiwan)

Abstract

Background : Air pollution has been associated with autoimmune diseases. Nephrotic syndrome is a clinical manifestation of immune-mediated glomerulopathy. However, the association between nephrotic syndrome and air pollution constituents remains unknown. We conducted this nationwide retrospective study to investigate the association between PM 2.5 and nephrotic syndrome. Methods : We used the Longitudinal Health Insurance Database (LHID) and the Taiwan Air Quality-Monitoring Database (TAQMD). We combined and stratified the LHID and the TAQMD data by residential areas of insurants linked to nearby air quality-monitoring stations. Air pollutant concentrations were grouped into four levels based on quartile. Univariable and multivariable Cox proportional hazard regression models were applied. Findings : Relative to Q1-level SO 2 , subjects exposed to the Q4 level were associated with a 2.00-fold higher risk of nephrotic syndrome (adjusted HR = 2.00, 95% CI = 1.66–2.41). In NOx, relative to Q1 NOx concentrations, the adjusted HRs of nephrotic syndrome risk were 1.53 (95% CI = 1.23–1.91), 1.30 (95% CI = 1.03–1.65), and 2.08 (95% CI = 1.69–2.56) for Q2, Q3, and Q4 levels, respectively. The results revealed an increasing trend for nephrotic syndrome risk correlating with increasing levels of NO, NO 2 , and PM 2.5 concentrations. Interpretation : High concentrations of PM 2.5 , NO, NO 2 , and SO 2 are associated with increased risk of nephrotic syndrome.

Suggested Citation

  • Shih-Yi Lin & Wu-Huei Hsu & Cheng-Li Lin & Cheng-Chieh Lin & Chih-Hsueh Lin & I-Kuan Wang & Chung-Y. Hsu & Chia-Hung Kao, 2018. "Association of Exposure to Fine-Particulate Air Pollution and Acidic Gases with Incidence of Nephrotic Syndrome," IJERPH, MDPI, vol. 15(12), pages 1-10, December.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:12:p:2860-:d:190608
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/12/2860/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/12/2860/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Shih, Yi-Hsuan & Shi, Nian-Xun & Tseng, Chao-Heng & Pan, Shu-Yuan & Chiang, Pen-Chi, 2016. "Socioeconomic costs of replacing nuclear power with fossil and renewable energy in Taiwan," Energy, Elsevier, vol. 114(C), pages 369-381.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shih-Yi Lin & Yu-Cih Yang & Cherry Yin-Yi Chang & Cheng-Chieh Lin & Wu-Huei Hsu & Shu-Woei Ju & Chung-Y. Hsu & Chia-Hung Kao, 2019. "Risk of Polycystic Ovary Syndrome in Women Exposed to Fine Air Pollutants and Acidic Gases: A Nationwide Cohort Analysis," IJERPH, MDPI, vol. 16(23), pages 1-14, November.
    2. Ji-Biao Zhang & Yu-Mei Rong & Qi-Feng Yin & Peng Zhang & Li-Rong Zhao & Chun-Liang Chen, 2022. "Spatiotemporal Variation and Influencing Factors of TSP and Anions in Coastal Atmosphere of Zhanjiang City, China," IJERPH, MDPI, vol. 19(4), pages 1-15, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chun Chih Chen, 2021. "The path to a 2025 nuclear-free Taiwan: An analysis of dynamic competition among emissions, energy, and economy," Energy & Environment, , vol. 32(4), pages 668-689, June.
    2. Wang, Ni & Verzijlbergh, Remco A. & Heijnen, Petra W. & Herder, Paulien M., 2023. "Incorporating indirect costs into energy system optimization models: Application to the Dutch national program Regional Energy Strategies," Energy, Elsevier, vol. 276(C).
    3. Osorio, Sebastian & van Ackere, Ann & Larsen, Erik R., 2017. "Interdependencies in security of electricity supply," Energy, Elsevier, vol. 135(C), pages 598-609.
    4. Hon Chung Lau & Steve C. Tsai, 2022. "A Decarbonization Roadmap for Taiwan and Its Energy Policy Implications," Sustainability, MDPI, vol. 14(14), pages 1-34, July.
    5. Kim, Ju-Hee & Yoo, Seung-Hoon, 2021. "Comparison of the economic effects of nuclear power and renewable energy deployment in South Korea," Renewable and Sustainable Energy Reviews, Elsevier, vol. 135(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:12:p:2860-:d:190608. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.