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Toxicity of Smokeless Tobacco Extract after 184-Day Repeated Oral Administration in Rats

Author

Listed:
  • Chenlin Yu

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
    Laboratory Animal Centre, Second Military Medical University, Shanghai 200433, China
    These authors contributed equally to this work.)

  • Ziteng Zhang

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
    These authors contributed equally to this work.)

  • Yangang Liu

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
    These authors contributed equally to this work.)

  • Ying Zong

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China)

  • Yongchun Chen

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China)

  • Xiuming Du

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China)

  • Jikuai Chen

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China)

  • Shijie Feng

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China)

  • Jinlian Hu

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China)

  • Shufang Cui

    (Laboratory Animal Centre, Second Military Medical University, Shanghai 200433, China)

  • Guocai Lu

    (Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China)

Abstract

The use of smokeless tobacco (ST) is growing rapidly and globally. The consumption of ST is associated with an increased risk for developing chronic diseases, such as diabetes, hypercholesterolemia, and myocardial infarction, and has led to many public health problems. It is very important to access the toxicity of ST. This experiment presents data from 184-day toxicology studies in Sprague-Dawley (SD) rats designed to characterize the chronic effects of a smokeless tobacco extract (STE). The control group and treatment groups were matched for a range of nicotine levels. Animals were given STE by oral gavage with doses of 3.75 (low-dose), 7.50 (mid-dose) and 15.00 (high-dose) mg·nicotine/kg body weight/day for 184 days, followed by 30 days for recovery. Variables evaluated included body weights, feed consumption, clinical observations, clinical and anatomic pathology (including organ weights), and histopathology. Decreased body weights and organ weights (heart, liver and kidney) were found in animals in the mid-dose and high-dose groups. STE also showed moderate and reversible toxicity in esophagus, stomach, liver, kidney and lung.

Suggested Citation

  • Chenlin Yu & Ziteng Zhang & Yangang Liu & Ying Zong & Yongchun Chen & Xiuming Du & Jikuai Chen & Shijie Feng & Jinlian Hu & Shufang Cui & Guocai Lu, 2016. "Toxicity of Smokeless Tobacco Extract after 184-Day Repeated Oral Administration in Rats," IJERPH, MDPI, vol. 13(3), pages 1-16, March.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:3:p:281-:d:65064
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    References listed on IDEAS

    as
    1. Daniel N. Willis & Mary A. Popovech & Francesca Gany & Carol Hoffman & Jason L. Blum & Judith T. Zelikoff, 2014. "Toxicity of Gutkha, a Smokeless Tobacco Product Gone Global: Is There More to the Toxicity than Nicotine?," IJERPH, MDPI, vol. 11(1), pages 1-15, January.
    2. Mejia, A.B. & Ling, P.M., 2010. "Tobacco industry consumer research on smokeless tobacco users and product development," American Journal of Public Health, American Public Health Association, vol. 100(1), pages 78-87.
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