IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v13y2016i11p1168-d83572.html
   My bibliography  Save this article

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Author

Listed:
  • Chunfeng Yun

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Zhenjie Wang

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Ping He

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Chao Guo

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Gong Chen

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Xiaoying Zheng

    (Institute of Population Research, Peking University, Beijing 100871, China)

Abstract

Although the prevalence of oral clefts in China is among the highest worldwide, little is known about the prevalence of speech disability associated with cleft palate in Chinese children. The data for this study were collected from the Second China National Sample Survey on Disability, and identification of speech disability associated with cleft palate was based on consensus manuals. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A weighted number of 112,070 disabled children affected by cleft palate were identified, yielding a prevalence of 3.45 per 10,000 children (95% CI: 3.19–3.71). A history of speech disability in the mother (OR = 20.266, 95% CI 5.788–70.959, p < 0.0001), older paternal child-bearing age (OR = 1.061, 95% CI 1.017–1.108, p = 0.0065, per year increase in age), and lower parental education (maternal: OR = 3.424, 95% CI 1.082–10.837, p = 0.0363; paternal: OR = 2.923, 95% CI 1.245–6.866, p = 0.0138) were strongly associated with risk of speech disability associated with cleft palate in the offspring. Our results showed that maternal speech disability, older paternal child-bearing age, and lower levels of parental education were independent risk factors for speech disability associated with cleft palate for children in China. These findings may have important implications for health disparities and prevention.

Suggested Citation

  • Chunfeng Yun & Zhenjie Wang & Ping He & Chao Guo & Gong Chen & Xiaoying Zheng, 2016. "Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey," IJERPH, MDPI, vol. 13(11), pages 1-8, November.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1168-:d:83572
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/13/11/1168/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/13/11/1168/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Lupo, P.J. & Danysh, H.E. & Symanski, E. & Langlois, P.H. & Cai, Y. & Swartz, M.D., 2015. "Neighborhood-based socioeconomic position and risk of oral clefts among offspring," American Journal of Public Health, American Public Health Association, vol. 105(12), pages 2518-2525.
    2. Augustine Kong & Michael L. Frigge & Gisli Masson & Soren Besenbacher & Patrick Sulem & Gisli Magnusson & Sigurjon A. Gudjonsson & Asgeir Sigurdsson & Aslaug Jonasdottir & Adalbjorg Jonasdottir & Wend, 2012. "Rate of de novo mutations and the importance of father’s age to disease risk," Nature, Nature, vol. 488(7412), pages 471-475, August.
    3. Kerstin U Ludwig & Syeda Tasnim Ahmed & Anne C Böhmer & Nasim Bahram Sangani & Sheryil Varghese & Johanna Klamt & Hannah Schuenke & Pinar Gültepe & Andrea Hofmann & Michele Rubini & Khalid Ahmed Aldho, 2016. "Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene," PLOS Genetics, Public Library of Science, vol. 12(3), pages 1-21, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fiona A. Hagenbeek & Jana S. Hirzinger & Sophie Breunig & Susanne Bruins & Dmitry V. Kuznetsov & Kirsten Schut & Veronika V. Odintsova & Dorret I. Boomsma, 2023. "Maximizing the value of twin studies in health and behaviour," Nature Human Behaviour, Nature, vol. 7(6), pages 849-860, June.
    2. Séverine Deguen & Wahida Kihal & Maxime Jeanjean & Cindy Padilla & Denis Zmirou-Navier, 2016. "Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-25, October.
    3. Jörn Bethune & April Kleppe & Søren Besenbacher, 2022. "A method to build extended sequence context models of point mutations and indels," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    4. Kitty Sherwood & Joseph C. Ward & Ignacio Soriano & Lynn Martin & Archie Campbell & Raheleh Rahbari & Ioannis Kafetzopoulos & Duncan Sproul & Andrew Green & Julian R. Sampson & Alan Donaldson & Kai-Re, 2023. "Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Wafeeq Abdelaziz, Asmaa & Ibrahim Abdelmageed, Reham, 2021. "An overview of non-genetic intellectual disability among Egyptian children and adolescents," Children and Youth Services Review, Elsevier, vol. 127(C).
    6. Marie Bernkopf & Ummi B. Abdullah & Stephen J. Bush & Katherine A. Wood & Sahar Ghaffari & Eleni Giannoulatou & Nils Koelling & Geoffrey J. Maher & Loïc M. Thibaut & Jonathan Williams & Edward M. Blai, 2023. "Personalized recurrence risk assessment following the birth of a child with a pathogenic de novo mutation," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    7. Hilary Cope & Edward R Ivimey-Cook & Jacob Moorad, 2022. "Triparental ageing in a laboratory population of an insect with maternal care [Male age alone predicts paternity success under sperm competition when effects of age and past mating effort are exper," Behavioral Ecology, International Society for Behavioral Ecology, vol. 33(6), pages 1123-1132.
    8. Stephanie M. Bilinovich & Kristy Lewis & Barbara L. Thompson & Jeremy W. Prokop & Daniel B. Campbell, 2020. "Environmental Epigenetics of Diesel Particulate Matter Toxicogenomics," IJERPH, MDPI, vol. 17(20), pages 1-13, October.
    9. Dang Ton Nguyen & Hai Ha Nguyen & Thuy Duong Nguyen & Thi Thanh Hoa Nguyen & Kaoru Nakano & Kazuhiro Maejima & Aya Sasaki-Oku & Van Ba Nguyen & Duy Bac Nguyen & Bach Quang Le & Jing Hao Wong & Tatsuhi, 2018. "Whole Genome Sequencing of a Vietnamese Family from a Dioxin Contamination Hotspot Reveals Novel Variants in the Son with Undiagnosed Intellectual Disability," IJERPH, MDPI, vol. 15(12), pages 1-11, November.
    10. Tetsushi Sadakata & Yo Shinoda & Akira Sato & Hirotoshi Iguchi & Chiaki Ishii & Makoto Matsuo & Ryosuke Yamaga & Teiichi Furuichi, 2013. "Mouse Models of Mutations and Variations in Autism Spectrum Disorder-Associated Genes: Mice Expressing Caps2/Cadps2 Copy Number and Alternative Splicing Variants," IJERPH, MDPI, vol. 10(12), pages 1-19, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1168-:d:83572. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.