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Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B 1

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  • Na Liang

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
    These authors contributed equally to this work.)

  • Fengyuan Wang

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
    These authors contributed equally to this work.)

  • Xi Peng

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China)

  • Jing Fang

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China)

  • Hengmin Cui

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China)

  • Zhengli Chen

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China)

  • Weimin Lai

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China)

  • Yi Zhou

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China)

  • Yi Geng

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China)

Abstract

To evaluate the renal toxicity of dietary aflatoxin B 1 (AFB 1 ) and ameliorating effects of added dietary sodium selenite in broiler, renal histopathological changes, ultrastructural changes, and renal function parameters were monitored at 7, 14, and 21 days of age. Two hundred one-day-old healthy male Avian broilers were divided into four groups, namely control group, AFB 1 group (0.3 mg/kg AFB 1 ), +Se group (0.4 mg/kg Se), and AFB 1 +Se group (0.3 mg/kg AFB 1 +0.4 mg/kg Se). Compared with that of the control group, the relative weight of kidney was increased in the AFB 1 group. There were no significant differences between the AFB 1 +Se group and the control group. By histopathological observation, the renal epithelia were swelling and necrosis at 7 and 21 days of age. Ultrastructurally, the lipid droplets and expanded endoplasmic reticulum appeared in the plasma of epithelia cells in the AFB 1 group. Enlarged mitochondria with degenerated cristae were observed in the +Se group. Compared with the control group, the contents of serum creatinine and serum uric acid in the AFB 1 group were increased, while the activity of renal Na + -K + ATPase was decreased. When 0.4 mg/kg selenium was added into the diet containing 0.3 mg/kg AFB 1 , there were no obvious histological changes in the AFB 1 +Se group, and the contents of the serum creatinine and serum uric acid contents and the activity of renal Na + -K + ATPase were close to those in the control group. In conclusion, sodium selenite exhibited protective effects on AFB 1 -induced kidney toxicity in broilers.

Suggested Citation

  • Na Liang & Fengyuan Wang & Xi Peng & Jing Fang & Hengmin Cui & Zhengli Chen & Weimin Lai & Yi Zhou & Yi Geng, 2015. "Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B 1," IJERPH, MDPI, vol. 12(9), pages 1-13, September.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:9:p:11196-11208:d:55460
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    References listed on IDEAS

    as
    1. Xi Peng & Shengqiang Zhang & Jing Fang & Hengmin Cui & Zhicai Zuo & Junliang Deng, 2014. "Protective Roles of Sodium Selenite against Aflatoxin B 1 -Induced Apoptosis of Jejunum in Broilers," IJERPH, MDPI, vol. 11(12), pages 1-14, December.
    2. Fengyuan Wang & Gang Shu & Xi Peng & Jing Fang & Kejie Chen & Hengmin Cui & Zhengli Chen & Zhicai Zuo & Junliang Deng & Yi Geng & Weimin Lai, 2013. "Protective Effects of Sodium Selenite against Aflatoxin B 1 -Induced Oxidative Stress and Apoptosis in Broiler Spleen," IJERPH, MDPI, vol. 10(7), pages 1-11, July.
    3. Kejie Chen & Xi Peng & Jing Fang & Hengmin Cui & Zhicai Zuo & Junliang Deng & Zhengli Chen & Yi Geng & Weimin Lai & Li Tang & Qingqiu Yang, 2014. "Effects of Dietary Selenium on Histopathological Changes and T Cells of Spleen in Broilers Exposed to Aflatoxin B 1," IJERPH, MDPI, vol. 11(2), pages 1-10, February.
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