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An index of the ratio of inflammatory to antiviral cell types mediates the effects of social adversity and age on chronic illness

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  • Simons, Ronald L.
  • Lei, Man-Kit
  • Beach, Steven R.H.
  • Barr, Ashley B.
  • Cutrona, Carolyn E.
  • Gibbons, Frederick X.
  • Philibert, Robert A.

Abstract

It is assumed that both social stress and chronological age increase the risk of chronic illness, in part, through their effect on systemic inflammation. Unfortunately, observational studies usually employ single-marker measures of inflammation (e.g., Interleukin-6, C-reactive protein) that preclude strong tests for mediational effects.

Suggested Citation

  • Simons, Ronald L. & Lei, Man-Kit & Beach, Steven R.H. & Barr, Ashley B. & Cutrona, Carolyn E. & Gibbons, Frederick X. & Philibert, Robert A., 2017. "An index of the ratio of inflammatory to antiviral cell types mediates the effects of social adversity and age on chronic illness," Social Science & Medicine, Elsevier, vol. 185(C), pages 158-165.
    • Handle: RePEc:eee:socmed:v:185:y:2017:i:c:p:158-165
    DOI: 10.1016/j.socscimed.2017.03.005
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    References listed on IDEAS

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    1. Cole, Steven W. & Conti, Gabriella & Arevalo, Jesusa M. & Ruggiero, Angela M. & Heckman, James J. & Suomi, Stephen J., 2012. "Transcriptional Modulation of the Developing Immune System by Early Life Social Adversity," IZA Discussion Papers 6915, Institute of Labor Economics (IZA).
    2. Simons, Ronald L. & Lei, Man Kit & Beach, Steven R.H. & Philibert, Robert A. & Cutrona, Carolyn E. & Gibbons, Frederick X. & Barr, Ashley, 2016. "Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women," Social Science & Medicine, Elsevier, vol. 150(C), pages 192-200.
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