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Theory and inference for regression models with missing responses and covariates

Author

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  • Chen, Qingxia
  • Ibrahim, Joseph G.
  • Chen, Ming-Hui
  • Senchaudhuri, Pralay

Abstract

In this paper, we carry out an in-depth theoretical investigation for inference with missing response and covariate data for general regression models. We assume that the missing data are missing at random (MAR) or missing completely at random (MCAR) throughout. Previous theoretical investigations in the literature have focused only on missing covariates or missing responses, but not both. Here, we consider theoretical properties of the estimates under three different estimation settings: complete case (CC) analysis, a complete response (CR) analysis that involves an analysis of those subjects with only completely observed responses, and the all case (AC) analysis, which is an analysis based on all of the cases. Under each scenario, we derive general expressions for the likelihood and devise estimation schemes based on the EM algorithm. We carry out a theoretical investigation of the three estimation methods in the normal linear model and analytically characterize the loss of information for each method, as well as derive and compare the asymptotic variances for each method assuming the missing data are MAR or MCAR. In addition, a theoretical investigation of bias for the CC method is also carried out. A simulation study and real dataset are given to illustrate the methodology.

Suggested Citation

  • Chen, Qingxia & Ibrahim, Joseph G. & Chen, Ming-Hui & Senchaudhuri, Pralay, 2008. "Theory and inference for regression models with missing responses and covariates," Journal of Multivariate Analysis, Elsevier, vol. 99(6), pages 1302-1331, July.
    • Handle: RePEc:eee:jmvana:v:99:y:2008:i:6:p:1302-1331
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    References listed on IDEAS

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    1. Joseph G. Ibrahim & Ming-Hui Chen & Stuart R. Lipsitz & Amy H. Herring, 2005. "Missing-Data Methods for Generalized Linear Models: A Comparative Review," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 332-346, March.
    2. Chen M-H. & Ibrahim J.G. & Shao Q-M., 2004. "Propriety of the Posterior Distribution and Existence of the MLE for Regression Models With Covariates Missing at Random," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 421-438, January.
    3. Joseph G. Ibrahim & Ming-Hui Chen & Stuart R. Lipsitz, 1999. "Monte Carlo EM for Missing Covariates in Parametric Regression Models," Biometrics, The International Biometric Society, vol. 55(2), pages 591-596, June.
    4. Qingxia Chen & Joseph G. Ibrahim, 2006. "Semiparametric Models for Missing Covariate and Response Data in Regression Models," Biometrics, The International Biometric Society, vol. 62(1), pages 177-184, March.
    5. Amy L. Stubbendick & Joseph G. Ibrahim, 2003. "Maximum Likelihood Methods for Nonignorable Missing Responses and Covariates in Random Effects Models," Biometrics, The International Biometric Society, vol. 59(4), pages 1140-1150, December.
    6. J. G. Ibrahim & S. R. Lipsitz & M.‐H. Chen, 1999. "Missing covariates in generalized linear models when the missing data mechanism is non‐ignorable," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 61(1), pages 173-190.
    7. Gong Tang, 2003. "Analysis of multivariate missing data with nonignorable nonresponse," Biometrika, Biometrika Trust, vol. 90(4), pages 747-764, December.
    8. Herring A. H & Ibrahim J. G, 2001. "Likelihood-Based Methods for Missing Covariates in the Cox Proportional Hazards Model," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 292-302, March.
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    Cited by:

    1. Fang, Fang & Shao, Jun, 2016. "Iterated imputation estimation for generalized linear models with missing response and covariate values," Computational Statistics & Data Analysis, Elsevier, vol. 103(C), pages 111-123.
    2. Ana M. Bianco & Paula M. Spano, 2019. "Robust inference for nonlinear regression models," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 28(2), pages 369-398, June.
    3. Joseph Ibrahim & Geert Molenberghs, 2009. "Missing data methods in longitudinal studies: a review," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 18(1), pages 1-43, May.
    4. Nian-Sheng Tang & Pu-Ying Zhao, 2013. "Empirical likelihood semiparametric nonlinear regression analysis for longitudinal data with responses missing at random," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 65(4), pages 639-665, August.
    5. Ana M. Bianco & Graciela Boente & Wenceslao González-Manteiga & Ana Pérez-González, 2019. "Plug-in marginal estimation under a general regression model with missing responses and covariates," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 28(1), pages 106-146, March.
    6. Bindele, Huybrechts F. & Nguelifack, Brice M., 2019. "Generalized signed-rank estimation for regression models with non-ignorable missing responses," Computational Statistics & Data Analysis, Elsevier, vol. 139(C), pages 14-33.
    7. Baojiang Chen & Xiao-Hua Zhou, 2011. "Doubly Robust Estimates for Binary Longitudinal Data Analysis with Missing Response and Missing Covariates," Biometrics, The International Biometric Society, vol. 67(3), pages 830-842, September.
    8. Yang, Miao & Das, Kalyan & Majumdar, Anandamayee, 2016. "Analysis of bivariate zero inflated count data with missing responses," Journal of Multivariate Analysis, Elsevier, vol. 148(C), pages 73-82.
    9. Nanhua Zhang & Roderick J. Little, 2012. "A Pseudo-Bayesian Shrinkage Approach to Regression with Missing Covariates," Biometrics, The International Biometric Society, vol. 68(3), pages 933-942, September.

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