Variable screening in predicting clinical outcome with high-dimensional microarrays
AbstractStatistical modeling is an important area of biomarker research of important genes for new drug targets, drug candidate validation, disease diagnoses, personalized treatment, and prediction of clinical outcome of a treatment. A widely adopted technology is the use of microarray data that are typically very high dimensional. After screening chromosomes for relative genes using methods such as quantitative trait locus mapping, there may still be a few thousands of genes related to the clinical outcome of interest. On the other hand, the sample size (the number of subjects) in a clinical study is typically much smaller. Under the assumption that only a few important genes are actually related to the clinical outcome, we propose a variable screening procedure to eliminate genes having negligible effects on the clinical outcome. Once the dimension of microarray data is reduced to a manageable number relative to the sample size, one can select a final set of genes via a well-known variable selection method such as the cross-validation. We establish the asymptotic consistency of the proposed variable screening procedure. Some simulation results are also presented.
Download InfoIf you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
Bibliographic InfoArticle provided by Elsevier in its journal Journal of Multivariate Analysis.
Volume (Year): 98 (2007)
Issue (Month): 8 (September)
Contact details of provider:
Web page: http://www.elsevier.com/wps/find/journaldescription.cws_home/622892/description#description
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- J. C. van Houwelingen, 2001. "Shrinkage and Penalized Likelihood as Methods to Improve Predictive Accuracy," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 55(1), pages 17-34.
- Luo, June, 2012. "Asymptotic efficiency of ridge estimator in linear and semiparametric linear models," Statistics & Probability Letters, Elsevier, vol. 82(1), pages 58-62.
- Luo, June, 2010. "The discovery of mean square error consistency of a ridge estimator," Statistics & Probability Letters, Elsevier, vol. 80(5-6), pages 343-347, March.
- Luo, June & Kulasekera, K.B., 2013. "Error covariance matrix estimation using ridge estimator," Statistics & Probability Letters, Elsevier, vol. 83(1), pages 257-264.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Zhang, Lei).
If references are entirely missing, you can add them using this form.