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Bayesian analysis of the patterns of biological susceptibility via reversible jump MCMC sampling


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  • Liu, Rui-Yin
  • Tao, Jian
  • Shi, Ning-Zhong
  • He, Xuming
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    In some biological experiments, it is quite common that laboratory subjects differ in their patterns of susceptibility to a treatment. Finite mixture models are useful in those situations. In this paper we model the number of components and the component parameters jointly, and base inference about these quantities on their posterior probabilities, making use of the reversible jump Markov chain Monte Carlo methods. In particular, we apply the methodology to the analysis of univariate normal mixtures with multidimensional parameters, using a hierarchical prior model that allows weak priors while avoiding improper priors in the mixture context. The practical significance of the proposed method is illustrated with a dose-response data set.

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    Article provided by Elsevier in its journal Computational Statistics & Data Analysis.

    Volume (Year): 55 (2011)
    Issue (Month): 3 (March)
    Pages: 1498-1508

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    Handle: RePEc:eee:csdana:v:55:y:2011:i:3:p:1498-1508

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    Keywords: Mixture normal models Model selection Classification Markov chain Monte Carlo method Reversible jump algorithms;


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    1. Tao, Jian & Shi, Ning-Zhong & Lee, S.-Y.Sik-Yum, 2004. "Drug risk assessment with determining the number of sub-populations under finite mixture normal models," Computational Statistics & Data Analysis, Elsevier, vol. 46(4), pages 661-676, July.
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    Cited by:
    1. Drovandi, Christopher C. & Pettitt, Anthony N. & Henderson, Robert D. & McCombe, Pamela A., 2014. "Marginal reversible jump Markov chain Monte Carlo with application to motor unit number estimation," Computational Statistics & Data Analysis, Elsevier, vol. 72(C), pages 128-146.
    2. Pandolfi, Silvia & Bartolucci, Francesco & Friel, Nial, 2014. "A generalized multiple-try version of the Reversible Jump algorithm," Computational Statistics & Data Analysis, Elsevier, vol. 72(C), pages 298-314.


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