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Joint analysis of mixed Poisson and continuous longitudinal data with nonignorable missing values

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  • Yang, Ying
  • Kang, Jian

Abstract

Regression models are proposed for joint analysis of Poisson and continuous longitudinal data with nonignorable missing values under fully parametric framework. Our primary interest is to evaluate the influence of the covariates on both Poisson and continuous responses. First, we form the full likelihood with complete data using the multivariate Poisson model and conditional multivariate normal distribution and then construct an ECM algorithm to find the maximum likelihood estimates of the model parameters. Then, under the assumption that the missingness mechanisms for the two responses are independent but nonignorable, namely, dependent on both observed and missing data of the two responses, we choose the logit model for the missingness mechanisms and selection model for the full likelihood. Also, we build two implementations of the Monte Carlo EM algorithm for estimating the parameters in the model. Wald test is employed to test the significance of covariates. Finally, we present the results of the Monte Carlo simulation to evaluate the performance of the proposed methodology and an application to the interstitial cystitis data base (ICDB) cohort study. To the best of our knowledge, our model is the first parametric model for joint analysis of Poisson and continuous longitudinal data with nonignorable missing value.

Suggested Citation

  • Yang, Ying & Kang, Jian, 2010. "Joint analysis of mixed Poisson and continuous longitudinal data with nonignorable missing values," Computational Statistics & Data Analysis, Elsevier, vol. 54(1), pages 193-207, January.
    • Handle: RePEc:eee:csdana:v:54:y:2010:i:1:p:193-207
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    References listed on IDEAS

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    1. Dimitris Karlis, 2003. "An EM algorithm for multivariate Poisson distribution and related models," Journal of Applied Statistics, Taylor & Francis Journals, vol. 30(1), pages 63-77.
    2. Joseph G. Ibrahim & Ming-Hui Chen & Stuart R. Lipsitz & Amy H. Herring, 2005. "Missing-Data Methods for Generalized Linear Models: A Comparative Review," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 332-346, March.
    3. Roy J. & Lin X., 2002. "Analysis of Multivariate Longitudinal Outcomes With Nonignorable Dropouts and Missing Covariates: Changes in Methadone Treatment Practices," Journal of the American Statistical Association, American Statistical Association, vol. 97, pages 40-52, March.
    4. J. G. Booth & J. P. Hobert, 1999. "Maximizing generalized linear mixed model likelihoods with an automated Monte Carlo EM algorithm," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 61(1), pages 265-285.
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    1. Xuerong Chen & Guoqing Diao & Jing Qin, 2020. "Pseudo likelihood‐based estimation and testing of missingness mechanism function in nonignorable missing data problems," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 47(4), pages 1377-1400, December.
    2. Wenqiong Xue & Jian Kang & F. DuBois Bowman & Tor D. Wager & Jian Guo, 2014. "Identifying functional co-activation patterns in neuroimaging studies via poisson graphical models," Biometrics, The International Biometric Society, vol. 70(4), pages 812-822, December.

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