IDEAS home Printed from https://ideas.repec.org/a/eee/csdana/v101y2016icp161-173.html
   My bibliography  Save this article

Multivariate frailty models for multi-type recurrent event data and its application to cancer prevention trial

Author

Listed:
  • Bedair, Khaled
  • Hong, Yili
  • Li, Jie
  • Al-Khalidi, Hussein R.

Abstract

Multi-type recurrent event data arise in many situations when two or more different event types may occur repeatedly over an observation period. For example, in a randomized controlled clinical trial to study the efficacy of nutritional supplements for skin cancer prevention, there can be two types of skin cancer events occur repeatedly over time. The research objectives of analyzing such data often include characterizing the event rate of different event types, estimating the treatment effects on each event process, and understanding the correlation structure among different event types. In this paper, we propose the use of a proportional intensity model with multivariate random effects to model such data. The proposed model can take into account the dependence among different event types within a subject as well as the treatment effects. Maximum likelihood estimates of the regression coefficients, variance–covariance components, and the nonparametric baseline intensity function are obtained via a Monte Carlo Expectation–Maximization (MCEM) algorithm. The expectation step of the algorithm involves the calculation of the conditional expectations of the random effects by using the Metropolis–Hastings sampling. Our proposed method can easily handle recurrent event data that have more than two types of events. Simulation studies were used to validate the performance of the proposed method, followed by an application to the skin cancer prevention data.

Suggested Citation

  • Bedair, Khaled & Hong, Yili & Li, Jie & Al-Khalidi, Hussein R., 2016. "Multivariate frailty models for multi-type recurrent event data and its application to cancer prevention trial," Computational Statistics & Data Analysis, Elsevier, vol. 101(C), pages 161-173.
    • Handle: RePEc:eee:csdana:v:101:y:2016:i:c:p:161-173
    DOI: 10.1016/j.csda.2016.01.018
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0167947316300044
    Download Restriction: Full text for ScienceDirect subscribers only.
    File URL: https://libkey.io/10.1016/j.csda.2016.01.018?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Hussein R. Al-Khalidi & Yili Hong & Thomas R. Fleming & Terry M. Therneau, 2011. "Insights on the Robust Variance Estimator under Recurrent-Events Model," Biometrics, The International Biometric Society, vol. 67(4), pages 1564-1572, December.
    2. D. Y. Lin & L. J. Wei & I. Yang & Z. Ying, 2000. "Semiparametric regression for the mean and rate functions of recurrent events," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(4), pages 711-730.
    3. J. G. Booth & J. P. Hobert, 1999. "Maximizing generalized linear mixed model likelihoods with an automated Monte Carlo EM algorithm," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 61(1), pages 265-285.
    4. Luc Duchateau & Paul Janssen & Iva Kezic & Catherine Fortpied, 2003. "Evolution of recurrent asthma event rate over time in frailty models," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 52(3), pages 355-363, July.
    5. Rondeau, Virginie & Marzroui, Yassin & Gonzalez, Juan R., 2012. "frailtypack: An R Package for the Analysis of Correlated Survival Data with Frailty Models Using Penalized Likelihood Estimation or Parametrical Estimation," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 47(i04).
    6. Gerda Claeskens & Rosemary Nguti & Paul Janssen, 2008. "One-sided tests in shared frailty models," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 17(1), pages 69-82, May.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hsiang Yu & Yu‐Jen Cheng & Ching‐Yun Wang, 2018. "Methods for multivariate recurrent event data with measurement error and informative censoring," Biometrics, The International Biometric Society, vol. 74(3), pages 966-976, September.
    2. Xiaowei Sun & Jieli Ding & Liuquan Sun, 2020. "A semiparametric additive rates model for the weighted composite endpoint of recurrent and terminal events," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(3), pages 471-492, July.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yassin Mazroui & Audrey Mauguen & Simone Mathoulin-Pélissier & Gaetan MacGrogan & Véronique Brouste & Virginie Rondeau, 2016. "Time-varying coefficients in a multivariate frailty model: Application to breast cancer recurrences of several types and death," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 22(2), pages 191-215, April.
    2. Bijwaard, Govert, 2011. "Unobserved Heterogeneity in Multiple-Spell Multiple-States Duration Models," IZA Discussion Papers 5748, Institute of Labor Economics (IZA).
    3. Miao Han & Liuquan Sun & Yutao Liu & Jun Zhu, 2018. "Joint analysis of recurrent event data with additive–multiplicative hazards model for the terminal event time," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 81(5), pages 523-547, July.
    4. Philip Hougaard, 2022. "Choice of time scale for analysis of recurrent events data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(4), pages 700-722, October.
    5. Chien-Lin Su & Russell J. Steele & Ian Shrier, 2021. "The semiparametric accelerated trend-renewal process for recurrent event data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 27(3), pages 357-387, July.
    6. Yang-Jin Kim, 2014. "Regression analysis of recurrent events data with incomplete observation gaps," Journal of Applied Statistics, Taylor & Francis Journals, vol. 41(7), pages 1619-1626, July.
    7. Per Kragh Andersen & Jules Angst & Henrik Ravn, 2019. "Modeling marginal features in studies of recurrent events in the presence of a terminal event," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(4), pages 681-695, October.
    8. Shu Yang & Jae Kwang Kim, 2016. "Likelihood-based Inference with Missing Data Under Missing-at-Random," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 43(2), pages 436-454, June.
    9. Na Cai & Wenbin Lu & Hao Helen Zhang, 2012. "Time-Varying Latent Effect Model for Longitudinal Data with Informative Observation Times," Biometrics, The International Biometric Society, vol. 68(4), pages 1093-1102, December.
    10. Julie K. Furberg & Per K. Andersen & Sofie Korn & Morten Overgaard & Henrik Ravn, 2023. "Bivariate pseudo-observations for recurrent event analysis with terminal events," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(2), pages 256-287, April.
    11. Hemant Kulkarni & Jayabrata Biswas & Kiranmoy Das, 2019. "A joint quantile regression model for multiple longitudinal outcomes," AStA Advances in Statistical Analysis, Springer;German Statistical Society, vol. 103(4), pages 453-473, December.
    12. Tatiyana V. Apanasovich & David Ruppert & Joanne R. Lupton & Natasa Popovic & Nancy D. Turner & Robert S. Chapkin & Raymond J. Carroll, 2008. "Aberrant Crypt Foci and Semiparametric Modeling of Correlated Binary Data," Biometrics, The International Biometric Society, vol. 64(2), pages 490-500, June.
    13. Dennis Schmidt & Rainer Schwabe, 2015. "On optimal designs for censored data," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 78(3), pages 237-257, April.
    14. Ricardo Smith Ramírez, 2007. "FIML estimation of treatment effect models with endogenous selection and multiple censored responses via a Monte Carlo EM Algorithm," Working papers DTE 403, CIDE, División de Economía.
    15. Xu, Wenjing & Pan, Qing & Gastwirth, Joseph L., 2014. "Cox proportional hazards models with frailty for negatively correlated employment processes," Computational Statistics & Data Analysis, Elsevier, vol. 70(C), pages 295-307.
    16. Xiaowei Sun & Jieli Ding & Liuquan Sun, 2020. "A semiparametric additive rates model for the weighted composite endpoint of recurrent and terminal events," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(3), pages 471-492, July.
    17. Brent A. Coull & Alan Agresti, 2000. "Random Effects Modeling of Multiple Binomial Responses Using the Multivariate Binomial Logit-Normal Distribution," Biometrics, The International Biometric Society, vol. 56(1), pages 73-80, March.
    18. Xiaoyu Wang & Liuquan Sun, 2023. "Joint modeling of generalized scale-change models for recurrent event and failure time data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(1), pages 1-33, January.
    19. J. E. Mills & C. A. Field & D. J. Dupuis, 2002. "Marginally Specified Generalized Linear Mixed Models: A Robust Approach," Biometrics, The International Biometric Society, vol. 58(4), pages 727-734, December.
    20. Jan Pablo Burgard & Patricia Dörr & Ralf Münnich, 2020. "Monte-Carlo Simulation Studies in Survey Statistics – An Appraisal," Research Papers in Economics 2020-04, University of Trier, Department of Economics.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:101:y:2016:i:c:p:161-173. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/csda .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.