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Pharmacokinetics of praziquantel and its metabolites in grass carp (Ctenopharyngodon idella) following the oral administration of a single bolus

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  • R Dobsikova

    (Department of Animal Husbandry, Animal Nutrition and Biochemistry, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • J Blahova

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • P Marsalek

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • V Doubkova

    (Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic)

  • E Zuskova

    (South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Vodnany, Czech Republic)

  • J Velisek

    (South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Vodnany, Czech Republic)

Abstract

The study aimed to evaluate and compare the routes and rates of the depletion of the antiparasitic praziquantel (PZQ), a derivative of pyrazinoisoquinoline, following its oral administration in grass carp (Ctenopharyngodon idella). We focused on the depletion of PZQ and its major metabolites - cis-hydroxy praziquantel (CPZQ) and trans-hydroxy praziquantel (TPZQ), in water, the plasma, hepatopancreas, kidney, muscle, and skin, following a single oral administration of PZQ in a concentration of 50 mg/kg. Fish were sampled before the drug administration and then eight times in the course of the 30-day-long experiment. Our results indicate the rapid absorption and elimination of PZQ and its metabolites in all the analysed matrices. The most PZQ-burdened tissue was the hepatopancreas, the gill and the skin. In all the samples, the concentration of the drug and its metabolites consistently declined over time. The residue of the parent compound was detected for the longest time in all the tissues. During the study, a significant (P < 0.01) correlation was found within the concentration of PZQ, CPZQ, and TPZQ in the water and all the biological matrices. It was also found that the PZQ residue was not detected below the maximum residue levels (i.e., 20 µg/kg) until 16 days after exposure in the muscle and skin.

Suggested Citation

  • R Dobsikova & J Blahova & P Marsalek & V Doubkova & E Zuskova & J Velisek, 2024. "Pharmacokinetics of praziquantel and its metabolites in grass carp (Ctenopharyngodon idella) following the oral administration of a single bolus," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 69(2), pages 52-60.
    • Handle: RePEc:caa:jnlvet:v:69:y:2024:i:2:id:109-2023-vetmed
    DOI: 10.17221/109/2023-VETMED
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    References listed on IDEAS

    as
    1. E Zuskova & V Piackova & O Valentova & K Zalohova & J Velisek, 2022. "Acute toxicity of praziquantel to fish Danio rerio and planktonic crustacean Daphnia magna," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(11), pages 579-584.
    2. J Kolarova & A Stara & E Zuskova & J Velisek, 2022. "Safety of the anthelminthic drugs levamisole, fenbendazole, and ivermectin administered in therapeutic baths for the common carp Cyprinus carpio," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(7), pages 371-378.
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    Keywords

    fish; food safety; health; parasites;
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