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Acute toxicity of praziquantel to fish Danio rerio and planktonic crustacean Daphnia magna

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  • E Zuskova

    (South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic)

  • V Piackova

    (South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic)

  • O Valentova

    (South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic)

  • K Zalohova

    (South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic)

  • J Velisek

    (South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic)

Abstract

This study evaluated the toxicity of the pyrazino isoquinoline anthelmintic praziquantel (PZQ) to the Danio rerio zebrafish and Daphnia magna water flea. The estimated 24 h and 96 h LC50 of PZQ to the zebrafish was 39.9 mg/l and 30.4 mg/l, respectively. The highest 24 h and 96 h non-lethal concentration (LC0) was 21.7 mg/l and 21.2 mg/l, respectively. The mobility inhibition test of the juvenile Daphnia magna revealed a 48 h EC50 of 42.7 mg/l.

Suggested Citation

  • E Zuskova & V Piackova & O Valentova & K Zalohova & J Velisek, 2022. "Acute toxicity of praziquantel to fish Danio rerio and planktonic crustacean Daphnia magna," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(11), pages 579-584.
    • Handle: RePEc:caa:jnlvet:v:67:y:2022:i:11:id:7-2022-vetmed
    DOI: 10.17221/7/2022-VETMED
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    Cited by:

    1. E Zuskova & J Velisek, 2024. "In-feed Praziquantel treatment of grass carp (Ctenopharyngodon idella) infected with eye flukes," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 69(1), pages 1-7.
    2. R Dobsikova & J Blahova & P Marsalek & V Doubkova & E Zuskova & J Velisek, 2024. "Pharmacokinetics of praziquantel and its metabolites in grass carp (Ctenopharyngodon idella) following the oral administration of a single bolus," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 69(2), pages 52-60.

    More about this item

    Keywords

    96 h LC50; antiparasitic; bath treatment; water flea; zebrafish;
    All these keywords.

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