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Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review

Author

Listed:
  • M. Bartos

    (Veterinary Research Institute, Brno, Czech Republic)

  • J. O. Falkinham III

    (Veterinary Research Institute, Brno, Czech Republic)

  • I. Pavlik

    (Veterinary Research Institute, Brno, Czech Republic)

Abstract

Mycobacteria are intracellular bacterial parasites which survive and proliferate inside of macrophages for long periods of time. Because mycobacterial survival in macrophages is required for virulence, a great deal of effort has been focused on identifying the genetic and physiologic determinants of intracellular survival and growth. A number of factors, among them catalases, peroxidases, and superoxide dismutase have been suggested as agents permitting mycobacteria to overcome the intracellular defences of macrophages. The characteristic features of mycobacterial catalase/peroxidases and superoxide dismutase, their distribution within the genus Mycobacterium, and their mutual interactions in the inactivation of toxic oxygen products are reviewed. Focus is placed on evidence of the role of mycobacterial catalase-peroxidase and superoxide dismutase in virulence and on the role of catalase-peroxidase in susceptibility to isonicotinic acid hydrazide.

Suggested Citation

  • M. Bartos & J. O. Falkinham III & I. Pavlik, 2004. "Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 49(5), pages 161-170.
    • Handle: RePEc:caa:jnlvet:v:49:y:2004:i:5:id:5691-vetmed
    DOI: 10.17221/5691-VETMED
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    References listed on IDEAS

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    1. L. Dvorská & M. Bartoš & G. Martin & W. Erler & I. Pavlík, 2001. "Strategies for differentiation, identification and typing of medically important species of mycobacteria by molecular methods," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 46(11-12), pages 309-328.
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