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Dietary chitosan affects metabolism of arachidonic acid in weaned piglets

Author

Listed:
  • Jun-Liang Li

    (College of Animal Science, Inner Mongolia Agricultural University, Huhhot, P.R. China)

  • Yuan-Qing Xu

    (College of Animal Science, Inner Mongolia Agricultural University, Huhhot, P.R. China)

  • Bin-Lin Shi
  • Deng-Sheng Sun

    (College of Animal Science, Inner Mongolia Agricultural University, Huhhot, P.R. China)

  • Su-Mei Yan

    (College of Animal Science, Inner Mongolia Agricultural University, Huhhot, P.R. China)

  • Xiao-Yu Guo

    (College of Animal Science, Inner Mongolia Agricultural University, Huhhot, P.R. China)

Abstract

The effects of chitosan on immune function via arachidonic acid (AA) pathway in weaned piglets were investigated. A total of 180 piglets (Duroc × Yorkshire × Landrace) were randomly assigned to 5 dietary treatments and fed a basal diet supplemented with 0 (control), 100, 500, 1000, and 2000 mg chitosan/kg feed, respectively. Results showed that serum AA, prostaglandin E2 (PGE2), and leukotriene B4 (LTB4) contents in piglets were increased in a linear or quadratic dose-dependent manner with increasing chitosan on day 28 (P < 0.05). Chitosan increased serum cytosolic-phospholipase A2 (cPLA2) activity in a linear or quadratic dose-dependent manner on day 14 or 28, and improved 5-lipoxygenase (5-LOX) activity in a linear manner and cyclooxygenase-2 (COX-2) activity quadratically on day 28 (P < 0.05). Moreover, chitosan elevated gene expression of cPLA2 mRNA quadratically in the small intestine on days 14 and 28, increased the COX-2 mRNA expression in the duodenum or jejunum in a linear or quadratic manner on day 28, and improved the 5-LOX mRNA expression quadratically in the small intestine (P < 0.05). These results implied that the metabolism of AA was regulated by chitosan in a dose-dependent relationship, which may be one reason why chitosan affected immune function via AA pathway in weaned piglets.

Suggested Citation

  • Jun-Liang Li & Yuan-Qing Xu & Bin-Lin Shi & Deng-Sheng Sun & Su-Mei Yan & Xiao-Yu Guo, 2017. "Dietary chitosan affects metabolism of arachidonic acid in weaned piglets," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 62(2), pages 58-66.
    • Handle: RePEc:caa:jnlcjs:v:62:y:2017:i:2:id:39-2016-cjas
    DOI: 10.17221/39/2016-CJAS
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    References listed on IDEAS

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    1. Y. Xu & B. Shi & S. Yan & J. Li & T. Li & Y. Guo & X. Guo, 2014. "Effects of chitosan supplementation on the growth performance, nutrient digestibility, and digestive enzyme activity in weaned pigs," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 59(4), pages 156-163.
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    More about this item

    Keywords

    cytosolic-phospholipase A2; prostaglandin E2; leukotriene B4; 5-lipoxygenase; cyclooxygenase-2; mRNA expression;
    All these keywords.

    JEL classification:

    • A2 - General Economics and Teaching - - Economic Education and Teaching of Economics
    • E2 - Macroeconomics and Monetary Economics - - Consumption, Saving, Production, Employment, and Investment
    • B4 - Schools of Economic Thought and Methodology - - Economic Methodology

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