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Robust testing in generalized linear models by sign flipping score contributions

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  • Jesse Hemerik
  • Jelle J. Goeman
  • Livio Finos

Abstract

Generalized linear models are often misspecified because of overdispersion, heteroscedasticity and ignored nuisance variables. Existing quasi‐likelihood methods for testing in misspecified models often do not provide satisfactory type I error rate control. We provide a novel semiparametric test, based on sign flipping individual score contributions. The parameter tested is allowed to be multi‐dimensional and even high dimensional. Our test is often robust against the mentioned forms of misspecification and provides better type I error control than its competitors. When nuisance parameters are estimated, our basic test becomes conservative. We show how to take nuisance estimation into account to obtain an asymptotically exact test. Our proposed test is asymptotically equivalent to its parametric counterpart.

Suggested Citation

  • Jesse Hemerik & Jelle J. Goeman & Livio Finos, 2020. "Robust testing in generalized linear models by sign flipping score contributions," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 82(3), pages 841-864, July.
  • Handle: RePEc:bla:jorssb:v:82:y:2020:i:3:p:841-864
    DOI: 10.1111/rssb.12369
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    References listed on IDEAS

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    1. Jelle J. Goeman & Sara A. Van De Geer & Hans C. Van Houwelingen, 2006. "Testing against a high dimensional alternative," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(3), pages 477-493, June.
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    5. Jelle J. Goeman & Hans C. van Houwelingen & Livio Finos, 2011. "Testing against a high-dimensional alternative in the generalized linear model: asymptotic type I error control," Biometrika, Biometrika Trust, vol. 98(2), pages 381-390.
    6. Jesse Hemerik & Jelle Goeman, 2018. "Exact testing with random permutations," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 27(4), pages 811-825, December.
    7. Aldo Solari & Livio Finos & Jelle J. Goeman, 2014. "Rotation-based multiple testing in the multivariate linear model," Biometrics, The International Biometric Society, vol. 70(4), pages 954-961, December.
    8. Jesse Hemerik & Jelle J. Goeman, 2018. "False discovery proportion estimation by permutations: confidence for significance analysis of microarrays," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 80(1), pages 137-155, January.
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