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Titanschäume als Knochenimplantat

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  • Müller, Daniel Wyn

Abstract

Der Inhalt dieser Arbeit befasst sich mit einer allgemein gehaltenen Realisierbarkeitsstudie für die Verwendung von Titanschäumen als Implantate im Bereich des Knochens. Dabei werden zu Beginn die rechtlich vorgeschriebenen medizintechnischen Anforderungen für Medizinprodukte in diesem Anwendungsfall umrissen, um eine geeignete Vorgehensweise bei dieser Studie zu ermitteln. Desweiteren wird auf das spezielle Herstellungsverfahren und dessen Problemstellungen eingegangen, im Hinblick auf die Realisierbarkeit der Produktherstellung an sich. In einer Materialcharakterisierung wird die chemische Zusammensetzung der Prototypen ermittelt und anschließend in in vitro Zellkulturversuchen auf deren Biokompatibilität und Eignung für die erdachte Anwendung untersucht. Im Fokus der Analyse stehen dabei die Zytotoxizität, Proliferationstendenz und das Zellwachstum auf den signifikanten, beim Herstellungsprozess entstehenden Titanschaumoberflächen. Abschließend werden die Schäume, unter Verwendung eines Tetrakaidekaeder-Einheitszellenmodelles, in simulierter Knochengewebeinhärenz auf deren mechanische Eignung als Stützmatrix untersucht.

Suggested Citation

  • Müller, Daniel Wyn, 2012. "Titanschäume als Knochenimplantat," Beiträge der Hochschule Pforzheim 142, Pforzheim University.
    • Handle: RePEc:zbw:pfobei:142
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    1. Häfner, Ansgar (Ed.) & Jost, Norbert (Ed.) & Rau, Karl-Heinz (Ed.) & Scherr, Roland (Ed.) & Wehner, Christa (Ed.) & Beck, Hanno (Ed.), 2011. "Communication on Progress: PRME Report 2008," Beiträge der Hochschule Pforzheim 139, Pforzheim University.
    2. Neuer, Kim Dobbie, 2010. "Achieving Lisbon: The EU's R&D challenge. The role of the public sector and implications of US best practice on regional policymaking in Europe," Beiträge der Hochschule Pforzheim 137, Pforzheim University.
    3. Noll, Bernd, 2010. "Zehn Thesen zur Corporate Governance," Beiträge der Hochschule Pforzheim 138, Pforzheim University.
    4. Cleff, Thomas & Fischer, Lena & Sepúlveda, César & Walter, Nadine, 2010. "How global are global brands? An empirical brand equity analysis," Beiträge der Hochschule Pforzheim 136, Pforzheim University.
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